TPT1 and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		TPT1	SPP1
Gene Name		tumor protein, translationally-controlled 1	secreted phosphoprotein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Multivesicular Body Tubulin Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Poly(A) RNA Binding	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways			Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		25 interactors: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1D FANCA IKBKG LIG4 MCL1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		7178	6696
HPRD ID		15979	01325
Ensembl ID		ENSG00000133112	ENSG00000118785
Uniprot IDs		P13693 Q8TBK7	B7Z351 P10451 Q3LGB0
PDB IDs		1YZ1 2HR9 3EBM	3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Regulation Of Response To DNA Damage Stimulus Cell Communication By Electrical Coupling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Response To Organic Cyclic Compound Response To Glycoside Apoptotic Process Regulation Of The Force Of Heart Contraction Response To Radiation Programmed Cell Death Positive Regulation Of Mitotic Cell Cycle Cell Death Death Response To Steroid Hormone Response To Abiotic Stimulus Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Sodium Ion Export From Cell Response To Lipid Regulation Of Signaling Cardiac Muscle Contraction Response To Stimulus Regulation Of Heart Contraction Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Sodium Ion Export Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Potassium Ion Homeostasis Cellular Response To Steroid Hormone Stimulus Neuron Death Cell Cycle Heart Contraction Cellular Response To Organic Cyclic Compound Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Cellular Response To Lipid Regulation Of Cardiac Muscle Contraction Regulation Of Neurogenesis Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Apoptotic Process Muscle Contraction Regulation Of Cellular Process Negative Regulation Of Mitotic Cell Cycle Cellular Localization	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process
Tagcloud ?		2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed fact lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?		2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?		fact