TPT1 and ATP1A2

Number of citations of the paper that reports this interaction (PubMedID 15383549)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TPT1	ATP1A2
Description		tumor protein, translationally-controlled 1	ATPase Na+/K+ transporting subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Cytoplasm Endosome Endoplasmic Reticulum Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Cell Surface Intercalated Disc Membrane T-tubule Organelle Membrane Protein-containing Complex Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Vesicle
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding DNA-binding Transcription Factor Binding	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Steroid Binding Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Potassium Ion Binding Sodium Ion Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Calcium Ion Transport Intracellular Calcium Ion Homeostasis Response To Virus Stem Cell Population Maintenance Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Ectoderm Development	Neurotransmitter Uptake Behavioral Fear Response Regulation Of The Force Of Heart Contraction Regulation Of Respiratory Gaseous Exchange By Nervous System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Striated Muscle Contraction Cell Communication Blood Circulation Regulation Of Heart Contraction Regulation Of Blood Pressure Adult Locomotory Behavior Visual Learning Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Auditory Stimulus Neuronal Action Potential Propagation Regulation Of Vasoconstriction L-ascorbic Acid Metabolic Process Amygdala Development Olfactory Cortex Development Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Response To Nicotine Locomotory Exploration Behavior Sodium Ion Transmembrane Transport Response To Potassium Ion Sodium Ion Export Across Plasma Membrane Locomotion Fear Response Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Negative Regulation Of Striated Muscle Contraction ATP Metabolic Process Negative Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Glutamatergic Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Ouabain Bisacodyl Tegoprazan
Diseases			Familial or sporadic hemiplegic migraine Alternating hemiplegia of childhood
GWAS		Type 2 diabetes ( 25760438)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Response to antipsychotic treatment ( 23241943)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 CEBPA DBN1 EEF1A1 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 SNX6 SPP1 STEAP3 TRIP13 TUBB2A USP40 VHL	2 interacting genes: TIAM1 TPT1
Entrez ID		7178	477
HPRD ID		15979	01665
Ensembl ID		ENSG00000133112	ENSG00000018625
Uniprot IDs		A0A0B4J2C3 P13693	A0A0S2Z3W6 B4DIQ8 P50993
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stress DNA Damage Response Response To Steroid Hormone Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Blood Circulation Regulation Of System Process Regulation Of Apoptotic Signaling Pathway Translation Elongation Factor Activity Regulation Of Neurotransmitter Uptake Cell Communication By Electrical Coupling Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Blood Circulation Response To Radiation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Amyloid Fibril Formation Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Response To Metal Ion Identical Protein Binding Regulation Of Programmed Cell Death Protein Heterodimerization Activity Positive Regulation Of Proteolysis Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Response To Cytokine Negative Regulation Of RNA Biosynthetic Process Regulation Of Biological Quality Negative Regulation Of DNA-templated Transcription Response To Peptide Regulation Of Transport Steroid Hormone Binding P-type Potassium Transmembrane Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Apoptotic Signaling Pathway P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Regulation Of Neuron Apoptotic Process Cytosol Sodium Ion Binding	Negative Regulation Of Ectoderm Development
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