TPT1 and TUBB2A

Number of citations of the paper that reports this interaction (PubMedID 15870695)
55

Data Source:
BioGRID (unspecified method)

		TPT1	TUBB2A
Description		tumor protein, translationally-controlled 1	tubulin beta 2A class IIa
Image
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding DNA-binding Transcription Factor Binding	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Calcium Ion Transport Intracellular Calcium Ion Homeostasis Response To Virus Stem Cell Population Maintenance Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Ectoderm Development	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Cerebral Cortex Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Type 2 diabetes ( 25760438)	Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 CEBPA DBN1 EEF1A1 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 SNX6 SPP1 STEAP3 TRIP13 TUBB2A USP40 VHL	28 interacting genes: ACD ARL15 ARNT CHGB DISC1 DUX4 HGS HMMR LAMA4 LINC01554 OGT PAFAH1B3 POT1 PSMD11 PTPRS RABAC1 RIC8A RPA2 RPLP1 RSPH1 SAT1 SDC3 SERPINB9 TERF1 TK1 TNIK TPT1 UPF2
Entrez ID		7178	7280
HPRD ID		15979
Ensembl ID		ENSG00000133112	ENSG00000137267
Uniprot IDs		A0A0B4J2C3 P13693	Q13885
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE	7NVN 8V3O 8V3P
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stress DNA Damage Response Response To Steroid Hormone Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Blood Circulation Regulation Of System Process Regulation Of Apoptotic Signaling Pathway Translation Elongation Factor Activity Regulation Of Neurotransmitter Uptake Cell Communication By Electrical Coupling Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Blood Circulation Response To Radiation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Amyloid Fibril Formation Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Response To Metal Ion Identical Protein Binding Regulation Of Programmed Cell Death Protein Heterodimerization Activity Positive Regulation Of Proteolysis Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Response To Cytokine Negative Regulation Of RNA Biosynthetic Process Regulation Of Biological Quality Negative Regulation Of DNA-templated Transcription Response To Peptide Regulation Of Transport Steroid Hormone Binding P-type Potassium Transmembrane Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Apoptotic Signaling Pathway P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Regulation Of Neuron Apoptotic Process Cytosol Sodium Ion Binding	Telomeric DNA Binding Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Telomeric Loop Disassembly Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Spermidine Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Ectoderm Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Cell-cell Adhesion Involved In Gastrulation Glutamatergic Synapse
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