TPT1 and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 14623968)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TPT1	EEF1D
Description		tumor protein, translationally-controlled 1	eukaryotic translation elongation factor 1 delta
Image
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Calcium Ion Transport Intracellular Calcium Ion Homeostasis Response To Virus Stem Cell Population Maintenance Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Ectoderm Development	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation
Pathways			Eukaryotic Translation Elongation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Type 2 diabetes ( 25760438)	Schizophrenia ( 31268507)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 CEBPA DBN1 EEF1A1 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 SNX6 SPP1 STEAP3 TRIP13 TUBB2A USP40 VHL	45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1
Entrez ID		7178	1936
HPRD ID		15979	00560
Ensembl ID		ENSG00000133112	ENSG00000104529
Uniprot IDs		A0A0B4J2C3 P13693	B2RAR6 P29692
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE	2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stress DNA Damage Response Response To Steroid Hormone Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Blood Circulation Regulation Of System Process Regulation Of Apoptotic Signaling Pathway Translation Elongation Factor Activity Regulation Of Neurotransmitter Uptake Cell Communication By Electrical Coupling Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Blood Circulation Response To Radiation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Amyloid Fibril Formation Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Response To Metal Ion Identical Protein Binding Regulation Of Programmed Cell Death Protein Heterodimerization Activity Positive Regulation Of Proteolysis Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Response To Cytokine Negative Regulation Of RNA Biosynthetic Process Regulation Of Biological Quality Negative Regulation Of DNA-templated Transcription Response To Peptide Regulation Of Transport Steroid Hormone Binding P-type Potassium Transmembrane Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Apoptotic Signaling Pathway P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Regulation Of Neuron Apoptotic Process Cytosol Sodium Ion Binding	Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding
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