SPTBN2 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11461920)
0

Data Source:
HPRD (in vitro)

		SPTBN2	ACTA1
Description		spectrin beta, non-erythrocytic 2	actin alpha 1, skeletal muscle
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Membrane Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranodal Junction Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse Structural Constituent Of Postsynapse	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Regulation Of Postsynaptic Specialization Assembly Postsynapse Organization	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Bipolar disorder ( 21926972 28115744 31043756) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder (MTAG) ( 33479212)
Interacting Genes		11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 PCNT SPTA1 UNC13B	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		6712	58
HPRD ID		05404	00030
Ensembl ID		ENSG00000173898	ENSG00000143632
Uniprot IDs		A0A087WYQ1 O15020	P68133
PDB IDs		1WJM 1WYQ 6ANU	7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Cytoskeleton Structural Constituent Of Cytoskeleton Regulation Of Protein-containing Complex Disassembly Axon Lamellipodium Cortical Cytoskeleton Adherens Junction Cytoskeleton Organization Kinetochore Cell Cortex Microtubule Associated Complex Actin Cytoskeleton Cell Projection Morphogenesis Neuron Projection Morphogenesis Tau Protein Binding Regulation Of Organelle Organization Cell Projection Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Microtubule Cytoskeleton Positive Regulation Of Mini Excitatory Postsynaptic Potential Centrosome Positive Regulation Of Synaptic Vesicle Priming Homeostatic Process Cytosol Negative Regulation Of Protein-containing Complex Disassembly Actin Filament Actin Filament-based Process Regulation Of Transport Regulation Of Mitotic Metaphase/anaphase Transition Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Transporter Regulator Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Intercellular Bridge Beta2-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Protein Depolymerization Regulation Of Supramolecular Fiber Organization Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Microtubule Organizing Center Dense Core Granule Priming	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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