SPTBN2 and UNC13B

Number of citations of the paper that reports this interaction (PubMedID 9704016)
0

Data Source:
HPRD (two hybrid)

		SPTBN2	UNC13B
Description		spectrin beta, non-erythrocytic 2	unc-13 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Membrane Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranodal Junction Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse Structural Constituent Of Postsynapse	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Regulation Of Postsynaptic Specialization Assembly Postsynapse Organization	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 21926972 28115744 31043756) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder (MTAG) ( 33479212)	Parkinson's disease ( 21812969)
Interacting Genes		11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 PCNT SPTA1 UNC13B	12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		6712	10497
HPRD ID		05404	05785
Ensembl ID		ENSG00000173898	ENSG00000198722
Uniprot IDs		A0A087WYQ1 O15020	A0A1B0GUS7 A0A1B0GVW8 O14795
PDB IDs		1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?		Cytoskeleton Structural Constituent Of Cytoskeleton Regulation Of Protein-containing Complex Disassembly Axon Lamellipodium Cortical Cytoskeleton Adherens Junction Cytoskeleton Organization Kinetochore Cell Cortex Microtubule Associated Complex Actin Cytoskeleton Cell Projection Morphogenesis Neuron Projection Morphogenesis Tau Protein Binding Regulation Of Organelle Organization Cell Projection Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Microtubule Cytoskeleton Positive Regulation Of Mini Excitatory Postsynaptic Potential Centrosome Positive Regulation Of Synaptic Vesicle Priming Homeostatic Process Cytosol Negative Regulation Of Protein-containing Complex Disassembly Actin Filament Actin Filament-based Process Regulation Of Transport Regulation Of Mitotic Metaphase/anaphase Transition Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Transporter Regulator Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Intercellular Bridge Beta2-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Protein Depolymerization Regulation Of Supramolecular Fiber Organization Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Microtubule Organizing Center Dense Core Granule Priming	Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization
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