SPTBN2 and DCTN1

Number of citations of the paper that reports this interaction (PubMedID 11461920)
0

Data Source:
HPRD (in vivo)

		SPTBN2	DCTN1
Description		spectrin beta, non-erythrocytic 2	dynactin subunit 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Membrane Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranodal Junction Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cilium Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Cell Leading Edge Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse Structural Constituent Of Postsynapse	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding
	Biological Process	Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Regulation Of Postsynaptic Specialization Assembly Postsynapse Organization	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Melanosome Transport Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Perry syndrome Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
GWAS		Bipolar disorder ( 21926972 28115744 31043756) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder (MTAG) ( 33479212)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 PCNT SPTA1 UNC13B	52 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 CTIF DCTN3 DISC1 DST DTNBP1 DYNC1I1 DYNC1I2 EEF1A1 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 LCOR MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B
Entrez ID		6712	1639
HPRD ID		05404	07206
Ensembl ID		ENSG00000173898	ENSG00000204843
Uniprot IDs		A0A087WYQ1 O15020	A0A7P0Z4C3 Q14203
PDB IDs		1WJM 1WYQ 6ANU	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Cytoskeleton Structural Constituent Of Cytoskeleton Regulation Of Protein-containing Complex Disassembly Axon Lamellipodium Cortical Cytoskeleton Adherens Junction Cytoskeleton Organization Kinetochore Cell Cortex Microtubule Associated Complex Actin Cytoskeleton Cell Projection Morphogenesis Neuron Projection Morphogenesis Tau Protein Binding Regulation Of Organelle Organization Cell Projection Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Microtubule Cytoskeleton Positive Regulation Of Mini Excitatory Postsynaptic Potential Centrosome Positive Regulation Of Synaptic Vesicle Priming Homeostatic Process Cytosol Negative Regulation Of Protein-containing Complex Disassembly Actin Filament Actin Filament-based Process Regulation Of Transport Regulation Of Mitotic Metaphase/anaphase Transition Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Transporter Regulator Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Intercellular Bridge Beta2-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Protein Depolymerization Regulation Of Supramolecular Fiber Organization Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Microtubule Organizing Center Dense Core Granule Priming	Cytosol Centrosome Microtubule-based Process Transport Along Microtubule Cytoskeleton Cytoskeleton-dependent Intracellular Transport Dynactin Binding Microtubule-based Transport Cytoplasm Organelle Transport Along Microtubule Microtubule-based Movement Cytoskeleton Organization Organelle Organization Minus-end-directed Organelle Transport Along Microtubule Protein Kinase Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Plus-end Binding Microtubule Organizing Center Execution Phase Of Apoptosis Microtubule Cell Cortex Dynactin Complex Organelle Assembly Hippocampus Development Positive Regulation Of Cilium Assembly Axon Ciliary Basal Body Response To Light Stimulus Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Cellular Component Organization Response To Radiation Pyroptotic Inflammatory Response Perinuclear Region Of Cytoplasm Vesicle Transport Along Microtubule Regulation Of Microtubule Cytoskeleton Organization Organelle Localization Microtubule Cytoskeleton Establishment Of Vesicle Localization Non-motile Cilium Assembly Protein Binding Central Region Of Growth Cone Vesicle Cytoskeletal Trafficking Brain Morphogenesis Dynein Complex Binding Retrograde Axonal Transport Vesicle Localization Protein Localization To Cilium Regulation Of Cytoskeleton Organization
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