SPTBN2 and ACTR1A

Number of citations of the paper that reports this interaction (PMID 11461920)
55

Data Source:
HPRD (in vivo)

		SPTBN2	ACTR1A
Gene Name		spectrin, beta, non-erythrocytic 2	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body	Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Associated Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding	ATP Binding
	Biological Process	Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Interaction between L1 and Ankyrins Axon guidance MHC class II antigen presentation L1CAM interactions NCAM signaling for neurite out-growth Adaptive Immune System	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 UNC13B	6 interactors: ACTR10 DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		6712	10121
HPRD ID		05404	05507
Ensembl ID		ENSG00000173898	ENSG00000138107
Uniprot IDs		O15020	P61163
PDB IDs		1WJM 1WYQ
Enriched GO Terms of Interacting Partners?		Organelle Organization Nervous System Development Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Neuron Development Cell Development Cell Morphogenesis Multicellular Organismal Development Anatomical Structure Development Neuron Differentiation Cell Projection Organization Axon Development Immune System Process Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Generation Of Neurons Neurogenesis Homotypic Cell-cell Adhesion Regulation Of Protein Complex Assembly T Cell Differentiation In Thymus Cellular Component Assembly Positive Regulation Of Synaptic Vesicle Priming Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cytoskeleton Organization Negative Regulation Of Protein Complex Disassembly Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Protein Depolymerization Positive Regulation Of Synaptic Vesicle Exocytosis Skeletal Muscle Fiber Adaptation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Locomotion Single Organismal Cell-cell Adhesion Axonogenesis G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Actin Cytoskeleton Organization Response To Stimulus Regulation Of Cell Adhesion Vesicle-mediated Transport	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Actin Filament Capping Organelle Localization Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Mitotic Cell Cycle Process Negative Regulation Of Protein Complex Assembly Mitotic Cell Cycle Microtubule-based Process Establishment Of Localization In Cell Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Localization Common-partner SMAD Protein Phosphorylation Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition SMAD Protein Import Into Nucleus Microtubule-based Movement Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Cell Cycle Regulation Of Actin Cytoskeleton Organization Nuclear Migration Axon Guidance Vesicle-mediated Transport Regulation Of Actin Filament-based Process Cerebellar Purkinje Cell Layer Morphogenesis Cell Division Membrane Assembly Golgi To Plasma Membrane Protein Transport Regulation Of Cytoskeleton Organization Membrane Biogenesis Establishment Of Nucleus Localization Axonogenesis
Tagcloud ?			backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?			backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?