SPTBN2 and MINK1

Number of citations of the paper that reports this interaction (PMID 15032605)
1

Data Source:
HPRD (two hybrid)

		SPTBN2	MINK1
Gene Name		spectrin, beta, non-erythrocytic 2	misshapen-like kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Cell Junction Axon Dendrite Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping	Regulation Of Cell-matrix Adhesion Protein Phosphorylation Response To Stress JNK Cascade Synaptic Transmission Multicellular Organismal Development Regulation Of Cell-cell Adhesion Microvillus Assembly Regulation Of Cell Migration Actin Cytoskeleton Reorganization Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of JNK Cascade Protein Autophosphorylation Dendrite Morphogenesis Regulation Of Catalytic Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance MHC class II antigen presentation L1CAM interactions NCAM signaling for neurite out-growth Adaptive Immune System	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		9 interactors: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 UNC13B	14 interactors: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 TUBA1B YWHAB YWHAZ
Entrez ID		6712	50488
HPRD ID		05404	11366
Ensembl ID		ENSG00000173898	ENSG00000141503
Uniprot IDs		O15020	Q8N4C8
PDB IDs		1WJM 1WYQ
Enriched GO Terms of Interacting Partners?		Organelle Organization Nervous System Development Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Neuron Development Cell Development Cell Morphogenesis Multicellular Organismal Development Anatomical Structure Development Neuron Differentiation Cell Projection Organization Axon Development Immune System Process Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Generation Of Neurons Neurogenesis Homotypic Cell-cell Adhesion Regulation Of Protein Complex Assembly T Cell Differentiation In Thymus Cellular Component Assembly Positive Regulation Of Synaptic Vesicle Priming Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cytoskeleton Organization Negative Regulation Of Protein Complex Disassembly Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Protein Depolymerization Positive Regulation Of Synaptic Vesicle Exocytosis Skeletal Muscle Fiber Adaptation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Locomotion Single Organismal Cell-cell Adhesion Axonogenesis G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Actin Cytoskeleton Organization Response To Stimulus Regulation Of Cell Adhesion Vesicle-mediated Transport	Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cellular Component Assembly Transport Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Establishment Of Localization In Cell Microtubule-based Transport Negative Regulation Of Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Intracellular Transport Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Organelle Organization Positive Regulation Of Cation Channel Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Positive Regulation Of Apoptotic Signaling Pathway Axonogenesis Regulation Of Cellular Localization Cell Morphogenesis Negative Regulation Of Transporter Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Cell Development Negative Regulation Of Ion Transmembrane Transport Cell Projection Organization Lamellipodium Organization Positive Regulation Of Ion Transmembrane Transporter Activity Neuron Projection Morphogenesis Organelle Transport Along Microtubule Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transporter Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Mitochondrion Organization Immune Response Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Calcium-dependent Cell-cell Adhesion
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