KCNIP1 and AMPD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNIP1	AMPD3
Description		potassium voltage-gated channel interacting protein 1	adenosine monophosphate deaminase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Monoatomic Ion Channel Complex Cell Projection Synapse Kv4.3-KChIP1 Channel Complex	Extracellular Region Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Metal Ion Binding	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	IMP Biosynthetic Process AMP Catabolic Process Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process IMP Salvage AMP Metabolic Process
Pathways		Phase 1 - inactivation of fast Na+ channels	Neutrophil degranulation Purine salvage
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 34059833) Haemorrhoidal disease ( 33888516) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Nonunion in individuals with fractures ( 30680360) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27841878) Total cholesterol levels ( 30498476) Waist-hip index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: AMPD3 ASPH CIAO2A DAAM2 IL6ST KCND1 KCND2 KCND3 KCNIP2 LITAF NHLH2 NIF3L1 SOD3 SPP1 SPRED2 TBC1D25	2 interacting genes: AMPD1 KCNIP1
Entrez ID		30820	272
HPRD ID		06879	00041
Ensembl ID		ENSG00000182132	ENSG00000133805
Uniprot IDs		Q9NZI2	Q01432
PDB IDs		1S1E 2I2R 2NZ0 7E83 7E84 7F3F 7W6N 7W6T
Enriched GO Terms of Interacting Partners?		A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Kv4.2-KChIP2 Channel Complex Membrane Repolarization Action Potential Monoatomic Ion Channel Complex Regulation Of System Process Potassium Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Detection Of Calcium Ion Metal Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Action Potential Neuronal Cell Body Inorganic Ion Transmembrane Transport Dendritic Spine Postsynaptic Specialization Membrane Regulation Of Multicellular Organismal Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Membrane Potential Protein Homooligomerization Dendrite Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Monoatomic Ion Transport Postsynaptic Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Regulation Of Glial Cell Differentiation Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Protein Complex Oligomerization Kv4.3-KChIP1 Channel Complex Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Estradiol Secretion Cytoplasmic Side Of Late Endosome Membrane Metal Ion Binding AMP Deaminase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity	IMP Salvage AMP Deaminase Activity GMP Salvage Kv4.3-KChIP1 Channel Complex Deaminase Activity IMP Biosynthetic Process GMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane IMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process GMP Metabolic Process Purine Nucleotide Salvage AMP Metabolic Process Membrane Repolarization Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Potassium Channel Regulator Activity Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Nucleoside Monophosphate Metabolic Process Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Potassium Ion Transport Cytoplasmic Side Of Plasma Membrane
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