KCNIP1 and KCND2

Number of citations of the paper that reports this interaction (PubMedID 15358149)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KCNIP1	KCND2
Description		potassium voltage-gated channel interacting protein 1	potassium voltage-gated channel subfamily D member 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Monoatomic Ion Channel Complex Cell Projection Synapse Kv4.3-KChIP1 Channel Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Plasma Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Kv4.2-KChIP2 Channel Complex Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Metal Ion Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Membrane Repolarization
Pathways		Phase 1 - inactivation of fast Na+ channels	Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs			Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine
Diseases
GWAS		Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969)
Interacting Genes		16 interacting genes: AMPD3 ASPH CIAO2A DAAM2 IL6ST KCND1 KCND2 KCND3 KCNIP2 LITAF NHLH2 NIF3L1 SOD3 SPP1 SPRED2 TBC1D25	8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1
Entrez ID		30820	3751
HPRD ID		06879	09254
Ensembl ID		ENSG00000182132	ENSG00000184408
Uniprot IDs		Q9NZI2	A4D0V9 Q9NZV8
PDB IDs		1S1E 2I2R 2NZ0 7E83 7E84 7F3F 7W6N 7W6T	7E7Z 7E83 7E84 7E87 7E8B 7E8E 7E8H 7F0J 7F3F 7UK5 7UKC 7UKD 7UKE 7UKF 7UKG 7UKH
Enriched GO Terms of Interacting Partners?		A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Kv4.2-KChIP2 Channel Complex Membrane Repolarization Action Potential Monoatomic Ion Channel Complex Regulation Of System Process Potassium Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Detection Of Calcium Ion Metal Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Action Potential Neuronal Cell Body Inorganic Ion Transmembrane Transport Dendritic Spine Postsynaptic Specialization Membrane Regulation Of Multicellular Organismal Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Membrane Potential Protein Homooligomerization Dendrite Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Monoatomic Ion Transport Postsynaptic Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Regulation Of Glial Cell Differentiation Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Protein Complex Oligomerization Kv4.3-KChIP1 Channel Complex Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Estradiol Secretion Cytoplasmic Side Of Late Endosome Membrane Metal Ion Binding AMP Deaminase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity	Voltage-gated Potassium Channel Complex Potassium Channel Regulator Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Complex Regulation Of Transport Transmembrane Transporter Binding Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Dendrite Potassium Ion Transport Membrane Repolarization Metal Ion Transport Protein Localization To Cell Periphery Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Binding Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Protein Localization To Membrane P2Y1 Nucleotide Receptor Binding Hepatocyte Growth Factor Receptor Activity Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Transport Synapse Protein Phosphatase Binding Kv4.2-KChIP2 Channel Complex Kv4.3-KChIP1 Channel Complex Regulation Of Signal Transduction Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation Transmembrane Transport Localization Within Membrane Positive Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Potassium Channels A-type (transient Outward) Potassium Channel Activity AMPA Glutamate Receptor Clustering Regulation Of System Process Neuroligin Family Protein Binding Positive Regulation Of Chemotaxis
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