SLC2A3 and MTNR1A

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		SLC2A3	MTNR1A
Description		solute carrier family 2 member 3	melatonin receptor 1A
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Aggresome Secretory Granule Membrane Specific Granule Membrane Cell Projection Perikaryon Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Fructose Transmembrane Transporter Activity Galactose Transmembrane Transporter Activity Protein Binding D-glucose Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Carbohydrate Metabolic Process Fructose Transmembrane Transport Galactose Transmembrane Transport L-ascorbic Acid Metabolic Process D-glucose Import Transmembrane Transport Dehydroascorbic Acid Transport D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways		Cellular hexose transport Vitamin C (ascorbate) metabolism Neutrophil degranulation MECP2 regulates neuronal receptors and channels	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)
Interacting Genes		6 interacting genes: CREB3 CREB3L1 GOLGB1 MTNR1A MTNR1B SNTA1	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		6515	4543
HPRD ID		00686	02812
Ensembl ID		ENSG00000059804	ENSG00000168412
Uniprot IDs		P11169	P48039
PDB IDs		4ZW9 4ZWB 4ZWC 5C65 7CRZ 7SPS 7SPT	6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Response To Unfolded Protein Positive Regulation Of Deacetylase Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Localization To Pericentriolar Material Extracellular Matrix Constituent Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Syntrophin Complex CCR1 Chemokine Receptor Binding Release From Viral Latency Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Programmed Cell Death Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Blood Circulation CAMP Response Element Binding Protein Binding Membrane Nitric-oxide Synthase Binding CAMP Response Element Binding Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Hormone Binding Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Cytosolic Calcium Ion Concentration Dystrophin-associated Glycoprotein Complex Ventricular Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Induction Of Positive Chemotaxis Protein Localization To Centrosome G Protein-coupled Receptor Activity Mating Behavior Negative Regulation Of Signal Transduction Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Membrane Potential Regulation Of Circadian Sleep/wake Cycle, Sleep	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity
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