PARVA and FERMT3

Number of citations of the paper that reports this interaction (PubMedID 25086068)
64

Data Source:
BioGRID (pull down)

		PARVA	FERMT3
Description		parvin alpha	FERM domain containing kindlin 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Z Disc Anchoring Junction	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Integrin Binding Protein Binding Lipid Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Organization Actin Cytoskeleton Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly	Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Platelet degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778) Rheumatic heart disease ( 34106200)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)
Interacting Genes		15 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 OGT PXN UBE3A UBQLN1	11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15
Entrez ID		55742	83706
HPRD ID		16283	07440
Ensembl ID		ENSG00000197702	ENSG00000149781
Uniprot IDs		Q9NVD7	F5H3I6 Q86UX7
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB	2YS3 6V97 6V9G 7C3M
Enriched GO Terms of Interacting Partners?		Integrin Binding Substrate Adhesion-dependent Cell Spreading Cell-substrate Adhesion Anchoring Junction Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell Cortex Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Biosynthetic Process Glial Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Cell-substrate Adhesion Integrin Activation Positive Regulation Of Integrin Activation Positive Regulation Of Gene Expression Cytosol Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Adhesion Stress Fiber Chemical Homeostasis Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Cell Development Regulation Of Cell Junction Assembly Regulation Of Protein Localization Regulation Of Integrin Activation Positive Regulation Of Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Schwann Cell Development Regulation Of Cell Migration Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Protein Serine/threonine Kinase Binding	Anchoring Junction Focal Adhesion Regulation Of Spontaneous Synaptic Transmission Integrin Binding Cell Adhesion Regulation Of Neurotransmitter Uptake Cell-substrate Adhesion Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Adhesion Heterotypic Cell-cell Adhesion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Positive Regulation Of Intracellular Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substrate Adhesion-dependent Cell Spreading Myoblast Fate Specification Integrin Alpha7-beta1 Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex Visual Behavior Glial Cell Development Synaptic Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?