PARVA and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		PARVA	NFE2L1
Description		parvin alpha	NFE2 like bZIP transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Z Disc Anchoring Junction	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Lipid Binding Cholesterol Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Organization Actin Cytoskeleton Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Glutathione Metabolic Process Heme Biosynthetic Process Regulation Of Mitotic Nuclear Division Steroid Metabolic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Cell Redox Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Lipid Homeostasis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Odontoblast Differentiation Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778) Rheumatic heart disease ( 34106200)	Aspartate aminotransferase levels ( 33547301) Fasting glucose ( 34059833) Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 OGT PXN UBE3A UBQLN1	17 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3 UBE4A
Entrez ID		55742	4779
HPRD ID		16283	01223
Ensembl ID		ENSG00000197702	ENSG00000082641
Uniprot IDs		Q9NVD7	J9JIE5 Q14494
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?		Integrin Binding Substrate Adhesion-dependent Cell Spreading Cell-substrate Adhesion Anchoring Junction Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell Cortex Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Biosynthetic Process Glial Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Cell-substrate Adhesion Integrin Activation Positive Regulation Of Integrin Activation Positive Regulation Of Gene Expression Cytosol Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Adhesion Stress Fiber Chemical Homeostasis Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Cell Development Regulation Of Cell Junction Assembly Regulation Of Protein Localization Regulation Of Integrin Activation Positive Regulation Of Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Schwann Cell Development Regulation Of Cell Migration Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Protein Serine/threonine Kinase Binding	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Integrated Stress Response Signaling RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process ER-nucleus Signaling Pathway DNA Binding Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Release From Viral Latency Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Calcium Ion Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Transcription Regulator Complex Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Metabolic Process
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