PARVA and ILK

Number of citations of the paper that reports this interaction (PubMedID 11331308)
35

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PARVA	ILK
Description		parvin alpha	integrin linked kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Z Disc Anchoring Junction	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Organization Actin Cytoskeleton Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778) Rheumatic heart disease ( 34106200)	Malaria ( 31844061)
Interacting Genes		15 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 OGT PXN UBE3A UBQLN1	43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		55742	3611
HPRD ID		16283	03842
Ensembl ID		ENSG00000197702	ENSG00000166333
Uniprot IDs		Q9NVD7	Q13418 V9HWF0
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?		Integrin Binding Substrate Adhesion-dependent Cell Spreading Cell-substrate Adhesion Anchoring Junction Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell Cortex Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Biosynthetic Process Glial Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Cell-substrate Adhesion Integrin Activation Positive Regulation Of Integrin Activation Positive Regulation Of Gene Expression Cytosol Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Adhesion Stress Fiber Chemical Homeostasis Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Cell Development Regulation Of Cell Junction Assembly Regulation Of Protein Localization Regulation Of Integrin Activation Positive Regulation Of Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Schwann Cell Development Regulation Of Cell Migration Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Protein Serine/threonine Kinase Binding	Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin
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