PARVA and ILK

Number of citations of the paper that reports this interaction (PMID 11331308)
52

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PARVA	ILK
Gene Name		parvin, alpha	integrin-linked kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex
	Molecular Function	Actin Binding Protein Binding	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cilium Morphogenesis Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778)
Protein-Protein Interactions		10 interactors: ACTA1 APP ILK LIMS1 MAP2K1 MLH1 MOCOS PXN UBC UBE3A	35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		55742	3611
HPRD ID		16283	03842
Ensembl ID			ENSG00000166333
Uniprot IDs		J3KNQ4 Q9NVD7	B7Z1I0 B7Z418 Q13418
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAP Kinase Activity Cellular Component Assembly Cell Aging Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Protein Heterooligomerization Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Protein Complex Assembly Cell Development Positive Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation ERBB Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Cell Junction Assembly Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Stimulus Cell-substrate Adhesion Multicellular Organismal Development Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process	Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Difference) ?		apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
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