PARVA

Gene Name		parvin, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Actin Binding Protein Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cilium Morphogenesis Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778)
Protein-protein Interactions		10 interactors: ACTA1 APP ILK LIMS1 MAP2K1 MLH1 MOCOS PXN UBC UBE3A
Entrez ID		55742
HPRD ID		16283
Ensembl ID
Uniprot IDs		J3KNQ4 Q9NVD7
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAP Kinase Activity Cellular Component Assembly Cell Aging Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Protein Heterooligomerization Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Protein Complex Assembly Cell Development Positive Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation ERBB Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Cell Junction Assembly Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Stimulus Cell-substrate Adhesion Multicellular Organismal Development Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process
Tagcloud ?		apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms