PARVA and FERMT1

Number of citations of the paper that reports this interaction (PubMedID 25086068)
64

Data Source:
BioGRID (pull down)

		PARVA	FERMT1
Description		parvin alpha	FERM domain containing kindlin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Z Disc Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Cell Junction Ruffle Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Integrin Binding Actin Filament Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Organization Actin Cytoskeleton Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases			Kindler syndrome
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778) Rheumatic heart disease ( 34106200)	Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		15 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 OGT PXN UBE3A UBQLN1	4 interacting genes: ILK ITGB1 PARVA SRPK1
Entrez ID		55742	55612
HPRD ID		16283	06388
Ensembl ID		ENSG00000197702	ENSG00000101311
Uniprot IDs		Q9NVD7	Q49AC8 Q54A15 Q9BQL6
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?		Integrin Binding Substrate Adhesion-dependent Cell Spreading Cell-substrate Adhesion Anchoring Junction Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell Cortex Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Biosynthetic Process Glial Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Cell-substrate Adhesion Integrin Activation Positive Regulation Of Integrin Activation Positive Regulation Of Gene Expression Cytosol Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Adhesion Stress Fiber Chemical Homeostasis Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Cell Development Regulation Of Cell Junction Assembly Regulation Of Protein Localization Regulation Of Integrin Activation Positive Regulation Of Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Schwann Cell Development Regulation Of Cell Migration Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Protein Serine/threonine Kinase Binding	Cell-substrate Adhesion Magnesium Ion Binding Heterotypic Cell-cell Adhesion Anchoring Junction Focal Adhesion Substrate Adhesion-dependent Cell Spreading Cell-cell Adhesion Regulation Of Neural Precursor Cell Proliferation Integrin Binding Cell-matrix Adhesion Neural Precursor Cell Proliferation Cellular Component Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Integrin-mediated Signaling Pathway Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Smooth Muscle Cell Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Cell Migration Protein Localization To Cell Cortex Cytoskeleton Organization Cell Morphogenesis Lamellipodium Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Cell Motility Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Calcium-independent Cell-matrix Adhesion Regulation Of Collagen Catabolic Process Formation Of Radial Glial Scaffolds Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Cell Projection Organization C-X3-C Chemokine Binding Integrin Binding Involved In Cell-matrix Adhesion Myelin Sheath Abaxonal Region Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Spontaneous Synaptic Transmission
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