PARVA and LIMS1

Number of citations of the paper that reports this interaction (PMID 12432066)
43

Data Source:
HPRD (in vivo, in vitro)

		PARVA	LIMS1
Gene Name		parvin, alpha	LIM and senescent cell antigen-like domains 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cilium Morphogenesis Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Epithelial To Mesenchymal Transition Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Cell Junction Assembly Chordate Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Protein Heterooligomerization Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778)
Protein-Protein Interactions		10 interactors: ACTA1 APP ILK LIMS1 MAP2K1 MLH1 MOCOS PXN UBC UBE3A	12 interactors: EHMT2 HOXA1 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X
Entrez ID		55742	3987
HPRD ID		16283	03978
Ensembl ID			ENSG00000169756
Uniprot IDs		J3KNQ4 Q9NVD7	P48059
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP	1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAP Kinase Activity Cellular Component Assembly Cell Aging Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Protein Heterooligomerization Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Protein Complex Assembly Cell Development Positive Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation ERBB Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Cell Junction Assembly Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Stimulus Cell-substrate Adhesion Multicellular Organismal Development Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process	Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Cell Development Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Substrate Adhesion-dependent Cell Spreading Locomotion Regulation Of Cellular Process Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Artery Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Artery Development Embryonic Cranial Skeleton Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Size Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Kinase B Signaling Regulation Of Gene Expression Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Adhesion Cell Motility Regulation Of BMP Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Actin Filament-based Process Facial Nucleus Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Smooth Muscle Cell Chemotaxis Nerve Development Blastocyst Development
Tagcloud ?		apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms	accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin
Tagcloud (Difference) ?		apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms	accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin
Tagcloud (Intersection) ?