ACTN1 and MYOT

Number of citations of the paper that reports this interaction (PMID 10369880)
37

Data Source:
HPRD (in vivo)

		ACTN1	MYOT
Gene Name		actinin, alpha 1	myotilin
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Actin Cytoskeleton Z Disc Sarcolemma
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Alpha-actinin Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Muscle Contraction
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)	Heart rate ( 23583979)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	12 interactors: ACTN1 APP AXIN1 FLNA FLNC GPRASP2 LRP12 NME7 ST7 TFG TRIM55 TRIM63
Entrez ID		87	9499
HPRD ID		00020	04981
Ensembl ID		ENSG00000072110	ENSG00000120729
Uniprot IDs		P12814	B4DT68 Q9UBF9
PDB IDs		2EYI 2EYN	2KDG 2KKQ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Platelet Degranulation Actin Crosslink Formation Signal Transduction Signaling Platelet Activation Cell Junction Assembly Cell Communication Response To Stimulus Receptor Clustering Vesicle-mediated Transport Microtubule-based Process Cellular Response To Stimulus Exocytosis Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Blood Coagulation Hemostasis Synaptic Growth At Neuromuscular Junction Cellular Component Assembly Determination Of Left/right Symmetry Establishment Of Localization In Cell Determination Of Bilateral Symmetry Collateral Sprouting In Absence Of Injury Axial Mesoderm Formation Secretion By Cell Microtubule-based Transport Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Localization To Tight Junction Cytoskeleton-dependent Intracellular Transport Regulation Of Body Fluid Levels Neural Plate Anterior/posterior Regionalization Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Wound Healing Regulation Of Growth Transport Secretion Skeletal Muscle Atrophy Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axial Mesoderm Morphogenesis Olfactory Placode Formation Regulation Of Protein Import Into Nucleus Muscle Cell Development Cellular Localization Endocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Striated Muscle Atrophy Axon Choice Point Recognition Cell Activation
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	bag3 causative cryab desmin disorganizations dnajb6 encode fhl1 flnc focal hereditary hmerf hyaline inclusions mfm muscles myofibril myofibrillar myopathy name pathologically pathomechanisms quite spheroid summarized ttn unexpectedly vcp zasp
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	bag3 causative cryab desmin disorganizations dnajb6 encode fhl1 flnc focal hereditary hmerf hyaline inclusions mfm muscles myofibril myofibrillar myopathy name pathologically pathomechanisms quite spheroid summarized ttn unexpectedly vcp zasp
Tagcloud (Intersection) ?