ACTN1 and TES

Number of citations of the paper that reports this interaction (PMID 12695497)
15

Data Source:
HPRD (in vitro)

		ACTN1	TES
Gene Name		actinin, alpha 1	testis derived transcript (3 LIM domains)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Junction Protein Complex
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Cell Proliferation
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	12 interactors: ACTL7A ACTN1 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX
Entrez ID		87	26136
HPRD ID		00020	05833
Ensembl ID		ENSG00000072110	ENSG00000135269
Uniprot IDs		P12814	A4D0U5 Q9UGI8
PDB IDs		2EYI 2EYN	2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Regulation Of Cytoskeleton Organization Cell Morphogenesis Regulation Of Actin Filament Polymerization Cellular Component Assembly Neuron Differentiation Cell Junction Assembly Regulation Of Actin Polymerization Or Depolymerization Cell Projection Organization Regulation Of Actin Filament Length Locomotion Organelle Organization Response To Stimulus Nervous System Development Cell-substrate Junction Assembly Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Bundle Assembly Generation Of Neurons Regulation Of Stress Fiber Assembly Regulation Of Protein Complex Assembly Protein Homotetramerization Signal Transduction Platelet Degranulation Actin Filament Reorganization Involved In Cell Cycle Neurogenesis Regulation Of Organelle Organization Signaling Cell Development Response To External Stimulus System Development
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara
Tagcloud (Intersection) ?