ACTN1 and LPP

Number of citations of the paper that reports this interaction (PMID 12615977)
10

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ACTN1	LPP
Gene Name		actinin, alpha 1	LIM domain containing preferred translocation partner in lipoma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Focal Adhesion
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Protein Binding Zinc Ion Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Cell Adhesion Biological_process
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)	B cell non-Hodgkin lymphoma ( 23749188) Celiac disease ( 20190752 18311140) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Obesity-related traits ( 23251661) Renal function-related traits (BUN) ( 22797727) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 22951725 20410501) White matter integrity (interaction) ( 23218918)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	6 interactors: ACTN1 ATP5J2 ATRAID SCRIB SHPRH VASP
Entrez ID		87	4026
HPRD ID		00020	02828
Ensembl ID		ENSG00000072110	ENSG00000145012
Uniprot IDs		P12814	B7Z8W0 B7ZLW0 Q93052
PDB IDs		2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Protein Localization To Cell Junction Neural Tube Closure Neural Tube Formation Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Cyclin Catabolic Process Tube Formation Morphogenesis Of Embryonic Epithelium Protein Localization To Tight Junction Cochlear Nucleus Development Protein Localization To Adherens Junction Neural Tube Development Cell Junction Assembly Establishment Of Apical/basal Cell Polarity Synaptic Vesicle Targeting Astrocyte Cell Migration Actin Filament Organization Auditory Receptor Cell Stereocilium Organization Establishment Of Monopolar Cell Polarity Exocytosis Pons Development Negative Regulation Of Osteoblast Proliferation Auditory Receptor Cell Morphogenesis Activation Of Rac GTPase Activity Epithelial Tube Morphogenesis Mitochondrial ATP Synthesis Coupled Proton Transport Auditory Receptor Cell Development Actin Crosslink Formation Positive Regulation Of Receptor Recycling Tube Morphogenesis Inner Ear Receptor Stereocilium Organization
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	arousal behavioural correlation degree denenberg describes direction documented exhibit lateral lateralities medial mpp paw periods preference preferences regardless relations rodents seemingly side sp spatial states strength strong terms waters
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	arousal behavioural correlation degree denenberg describes direction documented exhibit lateral lateralities medial mpp paw periods preference preferences regardless relations rodents seemingly side sp spatial states strength strong terms waters
Tagcloud (Intersection) ?