ACTN1 and TSC1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		ACTN1	TSC1
Description		actinin alpha 1	TSC complex subunit 1
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Nucleus Cytoplasm Lysosome Lysosomal Membrane Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Protein-containing Complex TSC1-TSC2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Protein Folding Chaperone Complex
	Molecular Function	Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse	Protein Binding Hsp70 Protein Binding ATPase Inhibitor Activity Protein Folding Chaperone Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response Protein Folding Potassium Ion Transport Cell-matrix Adhesion Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Cellular Response To Starvation Negative Regulation Of Macroautophagy Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATP-dependent Activity Response To Insulin Cellular Response To Decreased Oxygen Levels TORC1 Signaling Myelination Memory T Cell Differentiation Negative Regulation Of Cell Size D-glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs		Human calcitonin Copper
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 29403010 26805783 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX	169 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 C1orf94 CALCOCO2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FGFR4 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PRMT6 RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SAXO4 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 USP2-AS1 VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765
Entrez ID		87	7248
HPRD ID		00020	05594
Ensembl ID		ENSG00000072110	ENSG00000165699
Uniprot IDs		A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814	A0A2R8Y5M3 A0A2R8Y5N2 A0A2R8Y5S3 A0A2R8Y6S1 A0A2R8YD74 A0A2R8YFV7 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs		2EYI 2EYN 2N8Y 2N8Z	4Z6Y 5EJC 7DL2 9C9I 9CE3
Enriched GO Terms of Interacting Partners?		Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta	Cytoskeleton Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cytoplasm Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spindle Pole Microtubule-based Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of Biosynthetic Process Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Cytoskeleton Organization Organelle Organization Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition Cytoskeletal Protein Binding Cytosol Regulation Of Protein Localization Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Involved In Mitosis MAPK Cascade Cell Cycle Phase Transition Cell Division Positive Regulation Of Early Endosome To Late Endosome Transport Centrosome
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