ACTN1 and SPERT

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ACTN1	SPERT
Gene Name		actinin, alpha 1	spermatid associated
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	63 interactors: ACTN1 ARHGEF40 ARMC7 C14orf105 C19orf44 C1orf109 CCDC146 CCNG1 CDC23 CEP44 CEP57L1 CEP95 CHCHD3 CHIC2 CKS1B CNNM3 CTNNAL1 DGCR6 DUSP14 DZIP1L EIF4E2 ENKD1 FAM161A FRS3 GOLGA6L2 HAUS1 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 MED28 METTL17 MLH1 MMAB MOS NINL PID1 PIN1 PLEKHN1 PPP1R18 RPL9 RTP5 RUNX1T1 SCNM1 SH3RF2 SYCE1 TCEANC TCEB3 TEX11 TRIM42 TSC2 TSGA10 TUBGCP4 TXLNA TXLNB ZC2HC1C ZMAT2 ZNF564 ZNF581 ZNF655
Entrez ID		87	220082
HPRD ID		00020	14856
Ensembl ID		ENSG00000072110	ENSG00000174015
Uniprot IDs		P12814	Q8NA61
PDB IDs		2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Cell Cycle Process Cell Cycle Male Meiosis Chromosome Segregation Organelle Organization Regulation Of Cell Cycle Chromosome Segregation Negative Regulation Of Phosphorylation Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Synapsis Homologous Chromosome Segregation Negative Regulation Of Cell Cycle Resolution Of Meiotic Recombination Intermediates Negative Regulation Of MAPK Cascade Mitotic Cell Cycle Process Regulation Of Phosphorus Metabolic Process Microtubule-based Process Mitotic Cell Cycle Meiotic Chromosome Segregation Meiotic Cell Cycle Regulation Of Phosphorylation Chromosome Separation Regulation Of Protein Phosphorylation Synaptonemal Complex Assembly Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Synaptonemal Complex Organization Meiosis I Regulation Of Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Gene Expression G2/M Transition Of Mitotic Cell Cycle Metaphase Plate Congression Spindle Organization Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Meiotic Metaphase I Plate Congression Negative Regulation Of Mitochondrial DNA Replication Meiotic Spindle Midzone Assembly Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Protein Serine/threonine Kinase Activity Cellular Component Assembly Negative Regulation Of Transferase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Nuclear Division
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?