ACTN1 and ACTN3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ACTN1	ACTN3
Gene Name		actinin, alpha 1	actinin, alpha 3 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Protein Homodimerization Activity
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Muscle Filament Sliding Regulation Of Apoptotic Process Focal Adhesion Assembly
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions	Striated Muscle Contraction Nephrin interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	17 interactors: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		87	89
HPRD ID		00020	02148
Ensembl ID		ENSG00000072110	ENSG00000248746
Uniprot IDs		P12814	B4DZQ2 Q08043 Q4VAM3
PDB IDs		2EYI 2EYN	1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Protein Localization To Tight Junction Regulation Of Cell Death Cellular Component Assembly Protein Localization To Cell Junction Platelet Degranulation Regulation Of Apoptotic Process Actin Filament-based Process Actin Crosslink Formation Blood Coagulation Hemostasis Protein Polyubiquitination Focal Adhesion Assembly Platelet Activation Apoptotic Process Cell Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway NIK/NF-kappaB Signaling Cell-cell Junction Organization Programmed Cell Death Protein Autoubiquitination Cell Death Death Regulation Of Body Fluid Levels Tight Junction Assembly Adherens Junction Assembly Actin Cytoskeleton Organization Wound Healing Cytoskeleton Organization Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Protein Homooligomerization Positive Regulation Of Transporter Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cardiac Muscle Thin Filament Assembly Actin Filament Bundle Assembly Response To Wounding Regulation Of Signal Transduction Actin Filament Organization Apical Junction Assembly Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ion Transmembrane Transport Myofibril Assembly Exocytosis Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cytokine Production Adherens Junction Organization Regulation Of Signaling Cellular Response To Tumor Necrosis Factor
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance
Tagcloud (Intersection) ?