ACTN1 and CDK5R2

Number of citations of the paper that reports this interaction (PMID 12223541)
22

Data Source:
HPRD (in vitro, two hybrid)

		ACTN1	CDK5R2
Gene Name		actinin, alpha 1	cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Lipid Binding Cyclin-dependent Protein Kinase 5 Activator Activity
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	4 interactors: ACTB ACTN1 CAMK2A CDK5
Entrez ID		87	8941
HPRD ID		00020	04790
Ensembl ID		ENSG00000072110	ENSG00000171450
Uniprot IDs		P12814	Q13319
PDB IDs		2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Response To Wounding Peptidyl-serine Phosphorylation Membrane Organization Regulation Of Synaptic Plasticity Cell-matrix Adhesion Organelle Organization Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Response To Stress Protein Autophosphorylation Negative Regulation Of Synaptic Plasticity Cell-substrate Adhesion Cell Adhesion Protein Localization To Tight Junction Serine Phosphorylation Of STAT3 Protein Vesicle-mediated Transport Regulation Of Apoptotic Process Serine Phosphorylation Of STAT Protein Regulation Of Synaptic Transmission Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Death Exocytosis Regulation Of Synaptic Vesicle Recycling Protein Localization To Cell Junction Axon Guidance Cellular Component Assembly Transport Synaptic Transmission, Dopaminergic Establishment Of Localization In Cell Behavioral Response To Cocaine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization Secretion By Cell Axonogenesis Positive Regulation Of Calcium Ion-dependent Exocytosis Actin Crosslink Formation Corpus Callosum Development Protein Localization To Synapse Axon Development Receptor Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	aids ak1 biosynthesis cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	aids ak1 biosynthesis cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Intersection) ?