ACTN1 and MYOZ2

Number of citations of the paper that reports this interaction (PMID 11842093)
29

Data Source:
HPRD (in vivo)

		ACTN1	MYOZ2
Gene Name		actinin, alpha 1	myozenin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Actin Cytoskeleton Sarcomere Z Disc
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Biological_process
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	12 interactors: ACTN1 ACTN2 ACTN4 DRICH1 EWSR1 FLNC LDB3 MYB PPP3CA PPP3CB RBPMS ZDHHC17
Entrez ID		87	51778
HPRD ID		00020	05724
Ensembl ID		ENSG00000072110	ENSG00000172399
Uniprot IDs		P12814	Q9NPC6
PDB IDs		2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Protein Localization To Tight Junction Cell Activation Cell Junction Assembly Calcineurin-NFAT Signaling Cascade Protein Localization To Cell Junction Platelet Degranulation Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Exocytosis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Inositol Phosphate-mediated Signaling Actin Crosslink Formation Blood Coagulation Hemostasis Striated Muscle Cell Development Positive Regulation Of Intracellular Protein Transport Muscle Cell Development Regulation Of Protein Import Into Nucleus Secretion By Cell Platelet Activation Regulation Of Protein Localization To Nucleus Focal Adhesion Assembly Regulation Of Body Fluid Levels Cell-cell Junction Organization Regulation Of Nucleocytoplasmic Transport Wound Healing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Striated Muscle Cell Differentiation Regulation Of RNA Metabolic Process Secretion Actin Filament-based Process Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Intracellular Transport Tight Junction Assembly Regulation Of Intracellular Protein Transport Response To Wounding Adherens Junction Assembly Muscle Fiber Development Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Cellular Response To Drug Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transporter Activity Regulation Of Protein Localization Muscle Cell Differentiation Actin Filament Bundle Assembly Positive Regulation Of Protein Transport
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myozenin nfatc pp2b ppp3cb quantifying rcan1 s48p transgene unsettled
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myozenin nfatc pp2b ppp3cb quantifying rcan1 s48p transgene unsettled
Tagcloud (Intersection) ?