ACTN1 and CSRP3

Number of citations of the paper that reports this interaction (PMID 12642359)
29

Data Source:
HPRD (in vivo)

		ACTN1	CSRP3
Gene Name		actinin, alpha 1	cysteine and glycine-rich protein 3 (cardiac LIM protein)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome	Nucleus Cytoskeleton Z Disc
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding	Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Telethonin Binding Actinin Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis Skeletal Muscle Tissue Development Protein Localization To Organelle Detection Of Muscle Stretch Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction
Pathways		Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX	8 interactors: ACTN1 HDAC4 LDHD MYF6 MYOD1 MYOG NHLH1 SPTB
Entrez ID		87	8048
HPRD ID		00020	07525
Ensembl ID		ENSG00000072110	ENSG00000129170
Uniprot IDs		P12814	A2TDB8 P50461
PDB IDs		2EYI 2EYN	2O10 2O13
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development	Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Tissue Development Muscle Cell Fate Commitment Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Positive Regulation Of Myotube Differentiation Regulation Of Myoblast Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Muscle Cell Differentiation Response To Inactivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Cellular Response To Estradiol Stimulus Skeletal Muscle Fiber Development Positive Regulation Of Transcription, DNA-templated Skeletal Muscle Tissue Regeneration Cellular Response To Estrogen Stimulus Myotube Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Muscle System Process Muscle Organ Development Cell Fate Commitment Regulation Of Cell Development Transcription From RNA Polymerase II Promoter Muscle Fiber Development Striated Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Differentiation Tissue Regeneration Muscle Tissue Development Myotube Differentiation Cell Differentiation Positive Regulation Of Muscle Atrophy Transcription, DNA-templated RNA Biosynthetic Process
Tagcloud ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	actinin actn3 anabolic bout carp catabolic ck creatine eccentric extensions homozygotes investigates legs mafbx mrf4 murf myf5 myod1 myogenin myostatin nineteen protecting r577x rcan1 rr sarcomere satellite tended xx
Tagcloud (Difference) ?		b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	actinin actn3 anabolic bout carp catabolic ck creatine eccentric extensions homozygotes investigates legs mafbx mrf4 murf myf5 myod1 myogenin myostatin nineteen protecting r577x rcan1 rr sarcomere satellite tended xx
Tagcloud (Intersection) ?