ACTN1 and NUMBL

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ACTN1	NUMBL
Name		actinin alpha 1	NUMB like endocytic adaptor protein
Structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Cytoplasm Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse	Protein Binding
	Biological Process	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization	Nervous System Development Neuroblast Proliferation Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly
Pathways		Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle	None
Drugs		Human calcitonin Copper	None
GWAS		Asthma ( 31959851 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Feeling fed-up ( 29500382 ) Feeling hurt ( 29500382 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 ) High light scatter reticulocyte count ( 32888494 ) Lack of perseverance ( 30718321 ) Mean platelet volume ( 27863252 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Mosquito bite size ( 28199695 ) Neurociticism ( 29500382 ) Periodontitis (Mean PAL) ( 24024966 ) Platelet count ( 29403010 26805783 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Prostate cancer ( 23535732 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Smoking behavior ( 19247474 ) Urinary albumin excretion ( 30220432 )	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941 ) Carotid intima media thickness (mean) ( 31801372 ) Kawasaki disease ( 22446962 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) tricyclic pyrone compound response (IC50) ( 33610756 )
Interacting Genes		93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX	24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG
Entrez ID		87	9253
HPRD ID		00020	04931
Ensembl ID		ENSG00000072110	ENSG00000105245
Uniprot IDs		A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs		2EYI 2EYN 2N8Y 2N8Z	3F0W
GO Terms Enriched among Interactors		Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta	Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Protein Phosphorylation Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Developmental Process Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Cell Communication Endosome Membrane Positive Regulation Of Apoptotic Signaling Pathway Macromolecule Catabolic Process Regulation Of Apoptotic Process Canonical NF-kappaB Signal Transduction Cytosol Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process CD40 Receptor Complex Regulation Of Primary Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Signaling Adaptor Activity Positive Regulation Of Cell Population Proliferation