PRKAB2 and PRKAA2

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid, two hybrid)

		PRKAB2	PRKAA2
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	protein kinase, AMP-activated, alpha 2 catalytic subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Nucleoplasm Cytosol
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs		Adenosine monophosphate
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397
Entrez ID		5565	5563
HPRD ID		04117	02735
Ensembl ID		ENSG00000131791	ENSG00000162409
Uniprot IDs		O43741	P54646
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ	2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process
Tagcloud ?			amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Difference) ?			amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Intersection) ?