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PRKAA2 and TSC22D4
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PRKAA2
TSC22D4
Description
protein kinase AMP-activated catalytic subunit alpha 2
TSC22 domain family member 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Ciliary Basal Body
Neuronal Cell Body
Nucleus
Cytoplasm
Dendrite
Cell Projection
Synapse
Molecular Function
Nucleotide Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Protein Serine Kinase Activity
Histone H2BS36 Kinase Activity
Protein Binding
Biological Process
Cytoplasmic Translation
Chromatin Organization
Chromatin Remodeling
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Phosphatidylethanolamine Biosynthetic Process
Phosphatidylcholine Biosynthetic Process
Steroid Biosynthetic Process
Cholesterol Biosynthetic Process
Autophagy
Signal Transduction
Steroid Metabolic Process
Cholesterol Metabolic Process
Lipid Biosynthetic Process
Cellular Response To Starvation
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Sterol Biosynthetic Process
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
TORC1 Signaling
Cellular Response To Glucose Starvation
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Rhythmic Process
Fatty Acid Homeostasis
Protein Localization To Lysosome
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Xenobiotic Stimulus
Protein K6-linked Ubiquitination
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Energy Homeostasis
Hepatocyte Apoptotic Process
Positive Regulation Of Protein Localization
Negative Regulation Of Hepatocyte Apoptotic Process
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Protein Localization To Lipid Droplet
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Glucose Homeostasis
Negative Regulation Of DNA-templated Transcription
Neuron Cellular Homeostasis
Neuron Projection Extension
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine shuttle
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Nuclear events mediated by NFE2L2
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte count (
22286170
)
Brain morphology (MOSTest) (
32665545
)
Platelet count (
27863252
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SAXO4
SERTAD3
SKIC2
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBC
UBE2I
USH1C
USH1G
USHBP1
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
61 interacting genes:
ABLIM1
AIFM1
ARHGAP9
BLZF1
CBX8
CCDC146
CCDC33
CCDC42
CCNK
CDC23
CDK5R1
CKS2
CLU
CTNNAL1
ENKD1
FBXW7
FRMD6
FXR2
GOLGA2
GORASP2
KPNA2
KRT40
LBP
LMO1
LMO2
LNX1
LRP2BP
MAD2L1
MTHFS
MYLIP
MYO15B
NIF3L1
NOC4L
NRBP1
PCBP1
PCDH17
PIH1D1
PIN1
POLR1C
PPL
PRKAA1
PRKAA2
PRNP
PSMA1
RACK1
SACS
SAT1
SMAD3
SMARCB1
SYT17
TEX11
TLE5
TRIM55
TRIM63
TSC22D1
TSPOAP1
UBLCP1
VBP1
ZBTB24
ZMYND10
ZNF580
Entrez ID
5563
81628
HPRD ID
02735
18231
Ensembl ID
ENSG00000162409
ENSG00000166925
Uniprot IDs
P54646
B4DKI8
Q9Y3Q8
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
7MYJ
8BIK
Enriched GO Terms of Interacting Partners
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Protein Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Identical Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Cytosol
Supramolecular Fiber Organization
Cytoplasm
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Malonyl-CoA Biosynthetic Process
Acetyl-CoA Carboxylase Activity
Nucleus
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Prolactin
Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Cytoskeleton
Cellular Component Assembly
Autophagy
Regulation Of Growth
Transcription Factor Binding
Equilibrioception
Keratin Filament
Microtubule Motor Activity
Cullin Family Protein Binding
Microtubule
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Protein Binding
Organelle Organization
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Cytoplasm
Negative Regulation Of Protein Metabolic Process
Regulation Of Protein Stability
Negative Regulation Of Amyloid-beta Formation
Cellular Response To Glucose Stimulus
Phosphothreonine Residue Binding
Cellular Response To Hydrogen Peroxide
Protein Localization To Lipid Droplet
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Glucose Mediated Signaling Pathway
Regulation Of Glucose Mediated Signaling Pathway
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Carbohydrate Stimulus
Organelle Disassembly
Negative Regulation Of Tubulin Deacetylation
Negative Regulation Of Hepatocyte Apoptotic Process
AMP-activated Protein Kinase Activity
Regulation Of Amide Metabolic Process
Protein Stabilization
Regulation Of Protein Metabolic Process
Viral RNA Genome Replication
Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Intracellular Glucose Homeostasis
Protein Ubiquitination
Identical Protein Binding
Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Response To Hydrogen Peroxide
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Ubiquitin-protein Transferase Activator Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of Release Of Cytochrome C From Mitochondria
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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