PRKAA2 and ACACA

Number of citations of the paper that reports this interaction (PMID 2900138)
41

Data Source:
HPRD (in vitro)

		PRKAA2	ACACA
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	acetyl-CoA carboxylase alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Tissue Homeostasis Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Multicellular Organismal Protein Metabolic Process Small Molecule Metabolic Process Protein Homotetramerization Lipid Homeostasis Malonyl-CoA Biosynthetic Process
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism
Drugs			Biotin
Diseases
GWAS		Lymphocyte counts ( 22286170)	Ovarian cancer ( 23535730)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	9 interactors: ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 PRKAA1 PRKAA2 PRKAB1 PRKAG1
Entrez ID		5563	31
HPRD ID		02735	01938
Ensembl ID		ENSG00000162409	ENSG00000132142
Uniprot IDs		P54646	B2ZZ90 Q13085 Q7Z5W8
PDB IDs		2H6D 2LTU 2YZA 3AQV	2YL2 3COJ 4ASI
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Negative Regulation Of Cell Cycle Fatty Acid Biosynthetic Process Regulation Of Cell Cycle Cell Cycle Process Cell Cycle Fatty Acid Metabolic Process Regulation Of Glycolytic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Protein Phosphorylation Wnt Signaling Pathway Response To Insulin Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Chromosome Organization Response To Organonitrogen Compound Biosynthetic Process Regulation Of Gene Expression Response To Hormone Cellular Lipid Metabolic Process Phosphorylation Cellular Protein Modification Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Carboxylic Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Peptide Hormone Fatty Acid Homeostasis Protein Heterooligomerization Positive Regulation Of Metabolic Process Regulation Of Lipid Biosynthetic Process Signaling Response To Peptide Cell Communication Organic Acid Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Lipid Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Glucose Starvation Regulation Of Chromosome Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Checkpoint
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg
Tagcloud (Intersection) ?