PRKAA2 and NOTCH2NL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKAA2	NOTCH2NL
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	notch 2 N-terminal like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Region Cytoplasm
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Calcium Ion Binding
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587
Entrez ID		5563	388677
HPRD ID		02735	14833
Ensembl ID		ENSG00000162409	ENSG00000213240
Uniprot IDs		P54646	Q7Z3S9
PDB IDs		2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Intersection) ?