PRKAB2 and PRKAG3

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
BioGRID (two hybrid)

		PRKAB2	PRKAG3
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Extracellular Space Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	AMP-activated Protein Kinase Activity ATP Binding Protein Kinase Binding
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Glycogen Biosynthetic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Glucose Transport Intracellular Signal Transduction Membrane Organization
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs		Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	7 interactors: BRCA1 CRYAB LMCD1 NGRN PRKAA1 PRKAB1 PRKAB2
Entrez ID		5565	53632
HPRD ID		04117	16085
Ensembl ID		ENSG00000131791	ENSG00000115592
Uniprot IDs		O43741	B4DUK8 Q9UGI9
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Fatty Acid Biosynthetic Process Fatty Acid Metabolic Process Response To Hormone Negative Regulation Of Cell Cycle Cellular Response To Organonitrogen Compound Regulation Of Lipid Biosynthetic Process Response To Ionizing Radiation Cell Cycle Arrest Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Fatty Acid Biosynthetic Process Response To Organonitrogen Compound Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Lipid Metabolic Process Response To Gamma Radiation Carboxylic Acid Metabolic Process Cell Cycle Process Regulation Of Protein Metabolic Process Organic Acid Metabolic Process Protein Oligomerization Response To Radiation Negative Regulation Of Lipid Metabolic Process Response To Peptide Hormone Response To Organic Substance Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Peptide Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cell Cycle Cellular Response To Hormone Stimulus Response To Hydrogen Peroxide Positive Regulation Of Histone H3-K9 Acetylation Protein Heterooligomerization Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation
Tagcloud ?			accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire
Tagcloud (Difference) ?			accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire
Tagcloud (Intersection) ?