PRKAA2 and ACACB

Number of citations of the paper that reports this interaction (PubMedID 14613924)
0

Data Source:
HPRD (in vivo)

		PRKAA2	ACACB
Description		protein kinase AMP-activated catalytic subunit alpha 2	acetyl-CoA carboxylase beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Ciliary Basal Body Neuronal Cell Body	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Sterol Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Rhythmic Process Fatty Acid Homeostasis Protein Localization To Lysosome Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet	Acetyl-CoA Metabolic Process Pentose-phosphate Shunt Purine Nucleotide Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Fatty Acid Oxidation Response To Nutrient Levels Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Oxidation D-glucose Import Lactic Acid Secretion Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Fatty Acid Homeostasis Positive Regulation Of Heart Growth Response To Caloric Restriction Tricarboxylic Acid Metabolic Process Intracellular Aspartate Homeostasis Intracellular Glutamate Homeostasis Energy Homeostasis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Malonyl-CoA Biosynthetic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs Nuclear events mediated by NFE2L2 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP)
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Haloxyfop-P
Diseases
GWAS		Lymphocyte count ( 22286170)	Fish- and plant-related diet ( 32066663) Invasive cervical cancer ( 33794208) Liver enzyme levels (alkaline phosphatase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SAXO4 SERTAD3 SKIC2 SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBC UBE2I USH1C USH1G USHBP1 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23	4 interacting genes: HLCS PEX14 PRKAA2 USP7
Entrez ID		5563	32
HPRD ID		02735	07044
Ensembl ID		ENSG00000162409	ENSG00000076555
Uniprot IDs		P54646	O00763
PDB IDs		2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 7MYJ 8BIK	2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cytosol Supramolecular Fiber Organization Cytoplasm Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Malonyl-CoA Biosynthetic Process Acetyl-CoA Carboxylase Activity Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Prolactin Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytoskeleton Cellular Component Assembly Autophagy Regulation Of Growth Transcription Factor Binding Equilibrioception Keratin Filament Microtubule Motor Activity Cullin Family Protein Binding Microtubule	Post-translational Protein Modification Protein Modification Process Response To Nutrient Levels Negative Regulation Of TORC1 Signaling TORC1 Signaling Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Peroxisome Transport Along Microtubule Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of TOR Signaling TOR Signaling Response To Biotin Regulation Of TOR Signaling [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Biotin Metabolic Process Protein Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Oxidative Stress Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Positive Regulation Of Autophagy Protein Localization To Lipid Droplet Symbiont-mediated Disruption Of Host Cell PML Body Biotin Binding Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Hepatocyte Apoptotic Process Rhythmic Process Negative Regulation Of Tubulin Deacetylation Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Regulation Of Establishment Of Protein Localization To Telomere Cellular Response To Chemical Stress Lipid Droplet Disassembly Regulation Of Tubulin Deacetylation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Monoubiquitinated Protein Deubiquitination Regulation Of Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling Phosphatidylethanolamine Biosynthetic Process Response To Oxidative Stress Regulation Of Protein Deacetylation Nucleotide-activated Protein Kinase Complex Regulation Of Stress Granule Assembly DNA Alkylation Repair Protein Unfolding
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