PRKAA2 and PFKFB2

Number of citations of the paper that reports this interaction (PMID 12853467)
22

Data Source:
HPRD (in vitro)

		PRKAA2	PFKFB2
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Cytosol
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Lactate Metabolic Process Glycolytic Process Pathogenesis Response To Glucose Dephosphorylation Positive Regulation Of Insulin Secretion Positive Regulation Of Glucokinase Activity Small Molecule Metabolic Process Carbohydrate Phosphorylation
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	9 interactors: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ
Entrez ID		5563	5208
HPRD ID		02735	01383
Ensembl ID		ENSG00000162409	ENSG00000123836
Uniprot IDs		P54646	B4DY91 O60825
PDB IDs		2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Glucose Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Peptide Hormone Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Peptide Regulation Of Establishment Of Protein Localization Positive Regulation Of Signal Transduction Energy Reserve Metabolic Process Apoptotic Signaling Pathway Histone Phosphorylation Regulation Of Protein Localization Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Response To Peptide Hormone Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Glucose Homeostasis Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Glucose Import Negative Regulation Of Glucose Import Positive Regulation Of Glycolytic Process Regulation Of Cellular Localization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Intracellular Transport Regulation Of Signaling Cellular Response To Hormone Stimulus Regulation Of Mitochondrion Organization Negative Regulation Of Glucose Transport Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Regulation Of Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Response To Organonitrogen Compound Negative Regulation Of Transport Glucose Metabolic Process Chemical Homeostasis Generation Of Precursor Metabolites And Energy Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Intersection) ?