PRKAA2 and KRT31

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKAA2	KRT31
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	keratin 31, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Space Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Structural Constituent Of Cytoskeleton
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Epidermis Development
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	181 interactors: ABI2 AES AGR2 ALDH3B1 ALS2CR11 AMOT AMOTL2 ANKRD36BP1 AQP1 AQP5 ARHGAP35 ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 BEX2 BTC BYSL C12orf49 C19orf73 C1orf109 C1orf216 C5orf60 C6orf165 CA6 CARD9 CARKD CATIP CCDC112 CCDC120 CCDC17 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CEP57 CEP57L1 CEP70 CHCHD2 CHRNG CLDN2 COA5 COMT COX5A COX5B CRH CTSG DGCR6L DHX37 DMRT3 DTNB EIF4E2 EXOC8 FAM103A1 FAM110A FAM124B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FKBP1B FOXB1 GEM GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GPS2 GSTP1 HAUS1 HDAC4 HGS HOXA1 HSPA12B HSPD1 ICAM4 INPP5D INPP5K INSR JOSD1 KIFC3 KLC1 KLC4 KLHL38 KRT2 KRT5 KRT6A KRT6B KRT6C KRT71 KRT77 KRT79 KRT8 KRT81 KRT83 LATS1 LCE4A LENG1 LIN37 LINC00238 LINC00526 LMF2 LMO4 LONRF1 MAP3K7CL MAPKBP1 MARK4 MRPL40 NAV1 NEK6 NPBWR2 OTUB2 P2RX7 PDE4DIP PGLS PIN1 PKN1 PPP1R18 PRF1 PRKAA2 PRR19 PSMA1 PSMG2 PSPC1 PTGER3 PTPMT1 RADIL RCOR3 RIBC1 RPUSD3 RSPH14 SCNM1 SEMA4C SHC3 SIRPA SLC15A3 SLC23A1 SLC25A6 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPON2 SRSF2 SSX2IP TAPBPL THAP7 TMEM106C TMEM231 TMSB4X TRAF4 TROAP TSG101 TTC23 TXLNA USHBP1 UTP23 UXT WDR25 WDYHV1 ZFYVE21 ZNF124 ZNF148 ZNF20 ZNF569 ZNF572 ZNF69 ZNRF2P1
Entrez ID		5563	3881
HPRD ID		02735	03047
Ensembl ID		ENSG00000162409	ENSG00000094796
Uniprot IDs		P54646	Q15323
PDB IDs		2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Cellular Process Organelle Organization Epidermis Development Anatomical Structure Development Developmental Process Negative Regulation Of Cellular Metabolic Process Cytoskeleton Organization Positive Regulation Of Urine Volume G2/M Transition Of Mitotic Cell Cycle Gene Expression Regulation Of Body Fluid Levels Epithelium Development RNA Metabolic Process Regulation Of Interleukin-6 Production Carbon Dioxide Transport Response To Organic Substance Regulation Of Glycolytic Process Mitotic Cell Cycle Process Hippo Signaling Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-6 Production Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Pancreatic Juice Secretion Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Regulation Of MAPK Cascade Regulation Of Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cell Cycle Phase Transition Multicellular Organismal Development Bicarbonate Transport Cell Volume Homeostasis Cell Death Death Interaction With Symbiont Negative Regulation Of Signaling Transcription, DNA-templated Mitotic Cell Cycle Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Fungus Cellular Response To Extracellular Stimulus Cellular Metabolic Process Programmed Cell Death RNA Biosynthetic Process
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Intersection) ?