PRKAA2 and KIF24

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKAA2	KIF24
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	kinesin family member 24
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Centriole Cytosol Kinesin Complex Microtubule Protein Complex
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Organelle Organization Microtubule-based Movement Microtubule Depolymerization Metabolic Process Cilium Assembly
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	1 interactors: PRKAA2
Entrez ID		5563	347240
HPRD ID		02735	12963
Ensembl ID		ENSG00000162409	ENSG00000186638
Uniprot IDs		P54646	Q5T7B8
PDB IDs		2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Carnitine Shuttle Carnitine Transmembrane Transport Regulation Of Energy Homeostasis Carnitine Transport Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Quaternary Ammonium Group Transport Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Anion Homeostasis Regulation Of TOR Signaling Fatty Acid Transport Ammonium Transport Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Fatty Acid Metabolic Process Regulation Of Circadian Rhythm Regulation Of Autophagy Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process Peptidyl-serine Phosphorylation Sterol Metabolic Process Monocarboxylic Acid Transport Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Cellular Response To Starvation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Mitochondrial Transport Autophagy Cellular Response To Nutrient Levels Response To Starvation Glucose Homeostasis Cellular Response To Insulin Stimulus Cellular Response To Extracellular Stimulus Steroid Metabolic Process Inorganic Anion Transport Wnt Signaling Pathway Response To Insulin
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Intersection) ?