PRKAA2 and MYOZ1

Number of citations of the paper that reports this interaction (PMID 19616115)
4

Data Source:
BioGRID (two hybrid)

		PRKAA2	MYOZ1
Gene Name		protein kinase, AMP-activated, alpha 2 catalytic subunit	myozenin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Actin Cytoskeleton Pseudopodium
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Protein Binding FATZ Binding
	Biological Process	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis	Myofibril Assembly
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397	13 interactors: ACTN1 ACTN2 ACTN4 APP BRCA1 FLNC LDB3 MAGEA11 PNKP PRKAA2 TCAP TRIM55 TRIM63
Entrez ID		5563	58529
HPRD ID		02735	05725
Ensembl ID		ENSG00000162409	ENSG00000177791
Uniprot IDs		P54646	B4DUK4 Q9NP98
PDB IDs		2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process	Platelet Degranulation Protein Localization To Tight Junction Platelet Activation Cell Junction Assembly Protein Localization To Cell Junction Response To Abiotic Stimulus Actin Filament-based Process Cellular Component Assembly Exocytosis Actin Crosslink Formation Blood Coagulation Hemostasis Response To Stress Striated Muscle Cell Development Muscle Cell Development Secretion By Cell Actin-myosin Filament Sliding Focal Adhesion Assembly Muscle Filament Sliding Intracellular Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cytoskeleton Organization Cell-cell Junction Organization Regulation Of Body Fluid Levels Muscle Contraction Actin Cytoskeleton Organization Wound Healing Striated Muscle Cell Differentiation Secretion Actin-mediated Cell Contraction Tight Junction Assembly Adherens Junction Assembly Muscle System Process Cell Activation Muscle Fiber Development Response To Wounding Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Sarcomere Organization Positive Regulation Of Transporter Activity Actin Filament Organization Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Apoptotic Process Muscle Cell Differentiation Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Apical Junction Assembly Regulation Of Cell Death Positive Regulation Of Ion Transmembrane Transport
Tagcloud ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	adapt calcineurin calsarcin calsarcins changing demands disc distances enable fast fiber fibers ko modulates muscles myoblasts myopathic myozenin nfat organism overt rcan1 running sarcomeric skeletal slow striated tightly twitch
Tagcloud (Difference) ?		amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172	adapt calcineurin calsarcin calsarcins changing demands disc distances enable fast fiber fibers ko modulates muscles myoblasts myopathic myozenin nfat organism overt rcan1 running sarcomeric skeletal slow striated tightly twitch
Tagcloud (Intersection) ?