LRRC59 and MTNR1A

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LRRC59	MTNR1A
Gene Name		leucine rich repeat containing 59	melatonin receptor 1A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Mitochondrial Nucleoid	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Poly(A) RNA Binding	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		4 interactors: APP CSNK2A1 MTNR1A SGOL1	26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB
Entrez ID		55379	4543
HPRD ID		15181	02812
Ensembl ID		ENSG00000108829	ENSG00000168412
Uniprot IDs		Q96AG4	P48039
PDB IDs
Enriched GO Terms of Interacting Partners?		Mating Behavior Mating Synaptic Growth At Neuromuscular Junction Reproduction Collateral Sprouting In Absence Of Injury Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Peptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Centriole-centriole Cohesion Rhythmic Process Axon Choice Point Recognition Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Neuron Remodeling Regulation Of Endopeptidase Activity Axon Guidance Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Axonogenesis Positive Regulation Of CGMP Biosynthetic Process Cellular Copper Ion Homeostasis Positive Regulation Of CGMP Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Regulation Of CGMP Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Regulation Of Proteolysis Mitotic Cell Cycle Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of CGMP Metabolic Process Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle Endoplasmic Reticulum Calcium Ion Homeostasis Microtubule-based Process	Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
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