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PPP2R5E and SMAD9
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
PPP2R5E
SMAD9
Gene Name
protein phosphatase 2, regulatory subunit B, epsilon isoform
SMAD family member 9
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Cytoplasm
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Biological Process
Signal Transduction
Regulation Of Catalytic Activity
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Pathways
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Mitotic Anaphase
Signaling by Wnt
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Degradation of beta-catenin by the destruction complex
S37 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
CTLA4 inhibitory signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Cell Cycle, Mitotic
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Metaphase and Anaphase
Adaptive Immune System
Signaling by BMP
Drugs
Diseases
GWAS
Response to antineoplastic agents (
21659360
)
Protein-Protein Interactions
8 interactors:
APP
BHLHB9
CHEK2
PPP2CA
PPP2R1B
RACGAP1
SGOL1
SMAD9
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
Entrez ID
5529
4093
HPRD ID
09040
04484
Ensembl ID
ENSG00000120693
Uniprot IDs
B7Z5X1
B7Z7C0
B7ZAW5
B7ZKK9
J3KQN6
Q16537
Q59EK0
O15198
PDB IDs
Enriched GO Terms of Interacting Partners
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Mitotic Spindle Assembly
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Microtubule-based Process
Mitotic Spindle Organization
Mitotic Nuclear Division
Apoptotic Process
Programmed Cell Death
Cell Cycle Process
Reproduction
Developmental Process
Cell Death
Death
Cell Division
Spindle Assembly
Microtubule Cytoskeleton Organization
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Cytokinesis, Initiation Of Separation
Actomyosin Contractile Ring Assembly
Regulation Of Synapse Structure Or Activity
Regulation Of Cell Cycle Process
Cell Cycle
Synaptic Growth At Neuromuscular Junction
Regulation Of Receptor Activity
Regulation Of DNA Replication
Spindle Organization
Collateral Sprouting In Absence Of Injury
Regulation Of Cell Differentiation
Anatomical Structure Development
Collateral Sprouting
Axon Midline Choice Point Recognition
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Centriole-centriole Cohesion
Intracellular Signal Transduction
Meiotic Cell Cycle
Regulation Of Peptidyl-tyrosine Phosphorylation
Cellular Component Assembly
Axon Choice Point Recognition
Mitotic Spindle Midzone Assembly
Regulation Of Cell Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Cycle Process
Mitotic Spindle Elongation
Mitotic Cytokinetic Process
Mullerian Duct Regression
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Neuron Remodeling
Mitotic Nuclear Envelope Reassembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
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Tagcloud (Intersection)
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