PPP2R5E and PPP2R1B

Number of citations of the paper that reports this interaction (PMID 8703017)
87

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PPP2R5E	PPP2R1B
Gene Name		protein phosphatase 2, regulatory subunit B, epsilon isoform	protein phosphatase 2, regulatory subunit A, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm	Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Phosphatase Type 2A Regulator Activity	Protein Binding
	Biological Process	Signal Transduction Regulation Of Catalytic Activity	Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System	Signaling by GPCR Integration of energy metabolism Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		8 interactors: APP BHLHB9 CHEK2 PPP2CA PPP2R1B RACGAP1 SGOL1 SMAD9	31 interactors: AKAP9 ANXA5 BSG CDK1 CDK4 CFTR EEF2 FGFR1OP HDAC1 HSPD1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA SET SGOL1 SGOL2 STRN STRN3
Entrez ID		5529	5519
HPRD ID		09040	04384
Ensembl ID			ENSG00000137713
Uniprot IDs		B7Z5X1 B7Z7C0 B7ZAW5 B7ZKK9 J3KQN6 Q16537 Q59EK0	P30154
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Assembly Mitotic Cell Cycle Process Mitotic Cell Cycle Microtubule-based Process Mitotic Spindle Organization Mitotic Nuclear Division Apoptotic Process Programmed Cell Death Cell Cycle Process Reproduction Developmental Process Cell Death Death Cell Division Spindle Assembly Microtubule Cytoskeleton Organization Signal Transduction Involved In Intra-S DNA Damage Checkpoint Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Synapse Structure Or Activity Regulation Of Cell Cycle Process Cell Cycle Synaptic Growth At Neuromuscular Junction Regulation Of Receptor Activity Regulation Of DNA Replication Spindle Organization Collateral Sprouting In Absence Of Injury Regulation Of Cell Differentiation Anatomical Structure Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Centriole-centriole Cohesion Intracellular Signal Transduction Meiotic Cell Cycle Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Component Assembly Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Regulation Of Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Mitotic Spindle Elongation Mitotic Cytokinetic Process Mullerian Duct Regression Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Neuron Remodeling Mitotic Nuclear Envelope Reassembly	Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Response To Organic Substance Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cellular Response To Stimulus Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Ras Protein Signal Transduction Signal Transduction Regulation Of Catalytic Activity Response To Stimulus Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Inorganic Substance Cell Communication Regulation Of Cellular Process MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Reactive Oxygen Species Regulation Of Schwann Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Response To Organic Cyclic Compound Intracellular Signal Transduction Hydrogen Peroxide Metabolic Process Toll-like Receptor Signaling Pathway Response To Oxidative Stress Regulation Of Cell Death Cell Division Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Endomembrane System Organization G2/M Transition Of Mitotic Cell Cycle Response To CAMP Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Metabolic Process Chromosome Organization Activation Of Innate Immune Response Regulation Of Cellular Ketone Metabolic Process Reproduction Response To Organophosphorus
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