PPP2R5E and PPP2R1B

Number of citations of the paper that reports this interaction (PubMedID 17540176)
58

Data Source:
BioGRID (two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PPP2R5E	PPP2R1B
Description		protein phosphatase 2 regulatory subunit B'epsilon	protein phosphatase 2 scaffold subunit Abeta
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Signal Transduction	Spindle Assembly Meiotic Sister Chromatid Cohesion, Centromeric Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Schizophrenia ( 33169155) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)
Interacting Genes		23 interacting genes: APP BHLHE41 BTG3 BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DOCK9 ENO1 FBXW11 GPRASP3 OGT PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9	42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UBC UNC5B
Entrez ID		5529	5519
HPRD ID		09040	04384
Ensembl ID		ENSG00000154001	ENSG00000137713
Uniprot IDs		Q16537	P30154
PDB IDs		8UWB
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Circadian Rhythm Photoperiodism Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Small Molecule Metabolic Process Nucleus Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Carbohydrate Catabolic Process Response To Lead Ion Positive Regulation Of Circadian Rhythm Regulation Of ATP Metabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock Positive Regulation Of Proteolysis Negative Regulation Of Signal Transduction Regulation Of Proteolysis Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Regulation Of Glucose Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Response To Radiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Glycolytic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process E-box Binding Photoreceptor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphatase Type 2A Complex Circadian Regulation Of Gene Expression Protein Phosphatase Regulator Activity Cytosol Rhythmic Process Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peroxiredoxin Activity Regulation Of Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Sister Chromatid Cohesion Sister Chromatid Cohesion Cellular Response To Stress Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Removal Of Superoxide Radicals FAR/SIN/STRIPAK Complex Protein Phosphatase Activator Activity E-box Binding Positive Regulation Of Circadian Rhythm Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Schwann Cell Differentiation Response To Oxidative Stress Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Glucocorticoid Secretion Photoperiodism Regulation Of Programmed Cell Death Response To Reactive Oxygen Species Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 2A Binding Thioredoxin-dependent Peroxiredoxin Activity Nucleotide Binding Cytoplasm Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction Negative Regulation Of Neuron Apoptotic Process
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