AKIRIN2 and SPG21

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKIRIN2	SPG21
Gene Name		akirin 2	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	Enzyme Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Cell Proliferation Embryo Development Positive Regulation Of Endopeptidase Activity Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter	Antigen Receptor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CCDC85B LNX1 SPG21	37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		55122	51324
HPRD ID		12864	10492
Ensembl ID		ENSG00000135334	ENSG00000090487
Uniprot IDs		Q53H80 Q9NW35	Q9NZD8
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Tagcloud ?		3beta acts alpha5 anchorage bcam carcinogenesis detailed elucidate fbi1 glycoprotein hepatoma immunoglobulin k2 laminin lost lu luciferase lutheran oncogenes oncoprotein parental repressed repressor sickle splicing superfamily suppresses suppressive tumorigenicity
Tagcloud (Difference) ?		3beta acts alpha5 anchorage bcam carcinogenesis detailed elucidate fbi1 glycoprotein hepatoma immunoglobulin k2 laminin lost lu luciferase lutheran oncogenes oncoprotein parental repressed repressor sickle splicing superfamily suppresses suppressive tumorigenicity
Tagcloud (Intersection) ?