AKIRIN2 and UBR5

Number of citations of the paper that reports this interaction (PubMedID 37409633)
85

Data Source:
BioGRID (biochemical, enzymatic study)

		AKIRIN2	UBR5
Description		akirin 2	ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Transcription Repressor Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Proteasomal Protein Catabolic Process Protein Transport Cerebral Cortex Development Proteasome Localization Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Defense Response To Bacterium Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of B Cell Activation Regulation Of Muscle Cell Differentiation Nuclear Protein Quality Control By The Ubiquitin-proteasome System	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination
Pathways
Drugs
Diseases
GWAS			Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		11 interacting genes: CCDC85B FBXO7 HNRNPF HSD17B14 LNX1 MESD MYOZ3 NTAQ1 SORBS3 SPG21 UBR5	53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR
Entrez ID		55122	51366
HPRD ID		12864	06436
Ensembl ID		ENSG00000135334	ENSG00000104517
Uniprot IDs		Q53H80 Q9NW35	O95071
PDB IDs		7NHT	1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Ubiquitin-protein Transferase Activity Lewy Neurite D-threo-aldose 1-dehydrogenase Activity Protein-N-terminal Glutamine Amidohydrolase Activity	Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis
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