DTX3L and DTX1

Number of citations of the paper that reports this interaction (PubMedID 12670957)
0

Data Source:
HPRD (in vivo, in vitro)

		DTX3L	DTX1
Description		deltex E3 ubiquitin ligase 3L	deltex E3 ubiquitin ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Notch Signaling Pathway Endosome To Lysosome Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Binding Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process	DNA-templated Transcription Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination T Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)	Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		22 interacting genes: ANTXR1 DTX1 H2AC4 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U
Entrez ID		151636	1840
HPRD ID		16843	03991
Ensembl ID		ENSG00000163840	ENSG00000135144
Uniprot IDs		Q8TDB6	Q86Y01
PDB IDs		3PG6 8R79	6Y5N 6Y5P 8R5N 8R6A 8R6B
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Metabolic Process ATP Binding Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Nucleus Proteasomal Protein Catabolic Process ISG15-protein Conjugation Protein Catabolic Process Protein Autoubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cytosol Endosome Membrane Protein K6-linked Ubiquitination Ubiquitin-like Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process SUMO Conjugating Enzyme Activity NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity Nucleoplasm Regulation Of Signal Transduction Protein-containing Complex Global Genome Nucleotide-excision Repair ADP-D-ribose Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Protein Metabolic Process Notch Signaling Pathway Catabolic Process Proteolysis Protein Monoubiquitination Nucleotide Binding Protein Autoubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Intracellular Signal Transduction Ubiquitin-like Protein Ligase Binding Cellular Response To Tumor Cell Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of BMP Signaling Pathway Defense Response Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Atrioventricular Node Development Protein-containing Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Immune Response Macromolecule Metabolic Process Positive Regulation Of Receptor Catabolic Process Signal Transduction TORC1 Signaling Negative Regulation Of BMP Signaling Pathway STAT Family Protein Binding Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Innate Immune Response Response To External Biotic Stimulus
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