DTX3L and UBE2R2

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		DTX3L	UBE2R2
Description		deltex E3 ubiquitin ligase 3L	ubiquitin conjugating enzyme E2 R2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Notch Signaling Pathway Endosome To Lysosome Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Binding Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)	Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: ANTXR1 DTX1 H2AC4 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC
Entrez ID		151636	54926
HPRD ID		16843	15602
Ensembl ID		ENSG00000163840	ENSG00000107341
Uniprot IDs		Q8TDB6	Q712K3
PDB IDs		3PG6 8R79	6NYO 8PQL 8Q7R 8R5H
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Metabolic Process ATP Binding Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Nucleus Proteasomal Protein Catabolic Process ISG15-protein Conjugation Protein Catabolic Process Protein Autoubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cytosol Endosome Membrane Protein K6-linked Ubiquitination Ubiquitin-like Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process SUMO Conjugating Enzyme Activity NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity Nucleoplasm Regulation Of Signal Transduction Protein-containing Complex Global Genome Nucleotide-excision Repair ADP-D-ribose Binding	Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction
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