LSMEM2 and LSMEM1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LSMEM2	LSMEM1
Description		leucine rich single-pass membrane protein 2	leucine rich single-pass membrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		19 interacting genes: APP CD72 CLDN7 CLEC12B CTXN3 CXCL9 EMP1 GIMAP5 KLRC1 LSMEM1 PLN SEC22A SFTPC SGTA SMIM3 SPACA1 SPG21 TMEM143 TMEM218	6 interacting genes: APP CD53 LSMEM2 MAL TMEM80 ZDHHC15
Entrez ID		132228	286006
HPRD ID		08789	08258
Ensembl ID		ENSG00000179564	ENSG00000181016
Uniprot IDs		Q8N112	Q8N8F7
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Inhibitory Signaling Pathway Membrane Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Collateral Sprouting Negative Regulation Of Blood Circulation Regulation Of Calcium Ion Transmembrane Transport Neuron Maturation External Side Of Plasma Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Acrosome Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Carbohydrate Binding Inhibitory MHC Class Ib Receptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Locomotory Behavior	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Postsynapse Organization Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Localization Within Membrane Protein Insertion Into Plasma Membrane Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Targeting To Golgi Apparatus Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Developmental Maturation NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Establishment Of Protein Localization To Membrane Protein-cysteine S-stearoyltransferase Activity Membrane Raft Axon Choice Point Recognition
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