LSMEM2 and TMEM143

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSMEM2	TMEM143
Description		leucine rich single-pass membrane protein 2	transmembrane protein 143
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Mitochondrion Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding
	Biological Process		Biological_process
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: APP CD72 CLDN7 CLEC12B CTXN3 CXCL9 EMP1 GIMAP5 KLRC1 LSMEM1 PLN SEC22A SFTPC SGTA SMIM3 SPACA1 SPG21 TMEM143 TMEM218	14 interacting genes: ABHD16A AQP6 CSGALNACT2 DGAT2L6 DHRSX LIME1 LSMEM2 NAT8 ORMDL1 REEP6 SFT2D2 SLC10A6 TMEM120B YIPF2
Entrez ID		132228	55260
HPRD ID		08789	08556
Ensembl ID		ENSG00000179564	ENSG00000161558
Uniprot IDs		Q8N112	B4DMT0 B4DPF8 Q96AN5
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Inhibitory Signaling Pathway Membrane Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Collateral Sprouting Negative Regulation Of Blood Circulation Regulation Of Calcium Ion Transmembrane Transport Neuron Maturation External Side Of Plasma Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Acrosome Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Carbohydrate Binding Inhibitory MHC Class Ib Receptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Locomotory Behavior	Nitrate Transmembrane Transporter Activity Membrane Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus L-cysteine-S-conjugate N-acetyltransferase Activity Dolichal Reductase (NADPH) Activity Polyprenol Dehydrogenase (NAD+) Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Intracellular Transport Of Viral Protein In Host Cell Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Peptidyl-lysine N6-acetylation Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Acylglycerol Acyl-chain Remodeling Phospholipid Metabolic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Monoacylglycerol Catabolic Process B Cell Receptor Complex Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Bile Acid:sodium Symporter Activity Diacylglycerol O-acyltransferase Activity
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