MID2 and NCOA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MID2	NCOA4
Description		midline 2	nuclear receptor coactivator 4
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Extracellular Exosome	Nucleus Nucleoplasm Chromosome Lysosome Autophagosome Cytoplasmic Vesicle Autolysosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Viral Transcription Protein Localization To Microtubule Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Intracellular Signal Transduction	Protein Targeting To Lysosome Intracellular Iron Ion Homeostasis Male Gonad Development Response To Hormone Estrogen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus
Pathways			MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases			Thyroid cancer
GWAS			Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 20139978 29403010) Red blood cell count ( 29403010)
Interacting Genes		237 interacting genes: ADAMTSL4 AEN ALDH3B1 ANKS1A AP1M1 AQP1 ARHGEF5 ATOSA ATOSB ATRIP AXIN1 BAHD1 BCL6B BLK BLZF1 BRCA1 BRMS1L BYSL C1orf35 CALCOCO2 CARD9 CARHSP1 CBX8 CCDC120 CCDC185 CCDC187 CCDC33 CCDC42 CCHCR1 CDK18 CEP57L1 CFP CHD2 CNNM3 COX5B CPSF4 CRACR2A CREBRF CTSZ DCX DGCR6 DGCR6L DMRT3 DRC4 DYDC1 EFHC2 EGFL7 EIF1AD ELOA ENKD1 EPN2 ETNK2 FAM107A FAM161A FAM161B FAM50B FAM90A1 FARS2 FASTKD5 FBF1 FBXL18 FBXW5 FOXD4L3 FRMD6 FSD2 GAS2L2 GCC1 GEM GFI1B GMCL1 GOLGA2 GOLGA7 GORASP2 GPANK1 GPKOW GSC2 HAPLN2 HCK HDAC4 HDX HNRNPLL HOXB2 HOXB5 HOXB9 IGBP1 IGFN1 IHO1 IKZF3 IL16 INO80B IQCN ISCU ITGB4 JOSD1 KANK2 KIF1A KIF9 KIFC3 KRT27 KRT31 KRT40 KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS8 LMNB2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LRRC45 LZTS1 LZTS2 MAGEA6 MAGOHB MEOX1 MEOX2 METTL17 MFAP1 MID1 MID1IP1 MOS MVP NCOA4 NR1D2 NSMF NXF1 OTUB2 PICK1 PKN1 POLDIP3 PPP1R18 PRDM16 PRPF3 PRPF31 PSMA1 PTCD2 PTPDC1 QARS1 RABGEF1 RANBP3L RCOR3 REL RLN1 RNF6 RORB RPH3AL RPP25L RUNX1T1 RXRB SCNM1 SDCBP SEPTIN1 SHFL SLC25A48 SLC25A6 SNAI1 SNAP47 SPAG5 SPATA24 SPG21 SPRY2 STX11 SYNGAP1 TASOR2 TBC1D22B TCAF1 TCEA2 TCEANC TEKT1 THAP7 TMEM14B TOP3B TRIM27 TRIM29 TRIM32 TRIM41 TRIM42 TRIM54 TRIM69 TRPV6 TSGA10 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K UBE2U UBTD1 UNC45A USP2 USP25 USP54 UTP23 UTP25 WT1-AS ZBTB16 ZBTB24 ZBTB42 ZC2HC1C ZFYVE21 ZGPAT ZIM2 ZNF124 ZNF165 ZNF177 ZNF24 ZNF250 ZNF266 ZNF408 ZNF410 ZNF417 ZNF438 ZNF440 ZNF451 ZNF497 ZNF552 ZNF559-ZNF177 ZNF564 ZNF587 ZNF648 ZNF669 ZNF688 ZNF696 ZNF764 ZNF774 ZNF784 ZNF785 ZNF792 ZRANB1 ZSCAN12	12 interacting genes: AKT1 AR ATXN2 ESR1 GTF2B KAT2B MID2 NR3C1 PPARG RNF14 RXRA VDR
Entrez ID		11043	8031
HPRD ID		02191	03584
Ensembl ID		ENSG00000080561	ENSG00000266412
Uniprot IDs		Q6GX22 Q9UJV3	B2R5V0 Q13772 Q96E88
PDB IDs		2DJA 2DMK 7QRZ	1T5Z 8QU9
Enriched GO Terms of Interacting Partners?		Protein Binding Zinc Ion Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Ubiquitin Conjugating Enzyme Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Microtubule Binding Post-translational Protein Modification Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding Protein Polyubiquitination Cytoskeleton Negative Regulation Of RNA Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Protein Ubiquitination Regulation Of Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Identical Protein Binding	Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Estrogen Response Element Binding Cellular Response To Hormone Stimulus Enzyme Binding Regulation Of MiRNA Transcription DNA-templated Transcription Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process Zinc Ion Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process TBP-class Protein Binding Negative Regulation Of RNA Metabolic Process Steroid Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Maternal Process Involved In Female Pregnancy Vitamin D Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Hormone RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Chromatin Cellular Response To Lipoprotein Particle Stimulus DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II
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