TRAF5 and TNFRSF8

Number of citations of the paper that reports this interaction (PMID 8999898)
35

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		TRAF5	TNFRSF8
Gene Name		TNF receptor-associated factor 5	tumor necrosis factor receptor superfamily, member 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Cell Proliferation Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GORASP2 LTBR MAP3K14 MAP3K5 MAVS MDM2 NGFRAP1 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 USP7 ZFAND6	7 interactors: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		7188	943
HPRD ID		03834	01074
Ensembl ID		ENSG00000082512	ENSG00000120949
Uniprot IDs		D3DT93 O00463	A5D8T4 B9EGD9 D3YTD8 P28908
PDB IDs			1D01
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Immune Response Signal Transduction Apoptotic Process Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of MAPK Cascade Cell Communication Cellular Response To Organic Substance Regulation Of Apoptotic Process Response To Stimulus Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Response To Cytokine Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Cytokine Stimulus Positive Regulation Of MAP Kinase Activity Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Response To Organic Substance Regulation Of Immunoglobulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Regulation Of Lymphocyte Activation Defense Response Positive Regulation Of Protein Serine/threonine Kinase Activity	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Signaling NIK/NF-kappaB Signaling Cell Communication Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Protein Ubiquitination Response To Tumor Necrosis Factor Protein Modification By Small Protein Conjugation Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Innate Immune Response Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of MAP Kinase Activity Toll Signaling Pathway Cellular Response To Nitric Oxide CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine traf2 unexpected
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf6 transduction	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine unexpected
Tagcloud (Intersection) ?		traf2