TRAF5 and SERPINB9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAF5	SERPINB9
Description		TNF receptor associated factor 5	serpin family B member 9
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Process Cellular Response To Estrogen Stimulus
Pathways
Drugs			Raloxifene
Diseases
GWAS		Household income (MTAG) ( 31844048)	Left ventricular global circumferential strain ( 33495596) Plateletcrit ( 32888494) Vitiligo ( 27723757)
Interacting Genes		63 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COMMD3 DGKH DRC4 ENOX2 FAM9A GOLGA2 GORASP2 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655	28 interacting genes: BRD7 CASP1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1
Entrez ID		7188	5272
HPRD ID		03834	03480
Ensembl ID		ENSG00000082512	ENSG00000170542
Uniprot IDs		O00463	A0A024QZT4 P50453
PDB IDs		7L3L	8ZCR
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction PML Body Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Immune Response CD40 Signaling Pathway Protein Modification Process Protein Ubiquitination Post-translational Protein Modification Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity CD40 Receptor Complex Ubiquitin Protein Ligase Activity Protein Polyubiquitination Identical Protein Binding Protein K63-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cytoplasm Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Activation Ubiquitin-protein Transferase Activity JUN Kinase Kinase Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Response To Stress Protein Autoubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Signaling Adaptor Activity Intracellular Signaling Cassette Positive Regulation Of Cell Communication Adaptive Immune Response	Pyroptotic Cell Death NLRP1 Inflammasome Complex Pyroptotic Inflammatory Response Nuclear Matrix Canonical Inflammasome Complex Response To Osmotic Stress Interleukin-18-mediated Signaling Pathway Cellular Response To Type II Interferon CARD Domain Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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